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磷酸化状态依赖性的 Aβ 神经元内分拣会使自噬和内溶酶体系统受损。

Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system.

机构信息

Molecular Cell Biology, Department of Neurology, University Hospital Bonn, Bonn, Germany.

Neuroinflammation Unit, German Center for Neurodegenerative Diseases e. V. (DZNE), Bonn, Germany.

出版信息

Autophagy. 2024 Jan;20(1):166-187. doi: 10.1080/15548627.2023.2252300. Epub 2023 Aug 29.

DOI:10.1080/15548627.2023.2252300
PMID:37642583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10761119/
Abstract

AD

Alzheimer disease; APP: amyloid beta precursor protein; ATG: autophagy related; Aβ: amyloid-β; CTSD: cathepsin D; DAPI: 4',6-diamidino-2-phenylindole; EEA1: early endosome antigen 1; FA: formic acid; GFP: green fluorescent protein; LAMP2: lysosomal-associated membrane protein 2; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MAP2: microtubule-associated protein 2; nmAβ: non-modified amyloid-β; npAβ: non-phosphorylated amyloid-β; pAβ: phosphorylated amyloid-β; p-Ser26Aβ: amyloid-β phosphorylated at serine residue 26; p-Ser8Aβ: amyloid-β phosphorylated at serine residue 8; RAB: RAB, member RAS oncogene family; RFP: red fluorescent protein; SQSTM1/p62: sequestome 1; YFP: yellow fluorescent protein.

摘要

AD

阿尔茨海默病；APP：淀粉样前体蛋白；ATG：自噬相关；Aβ：淀粉样-β；CTSD：组织蛋白酶 D；DAPI：4'，6-二脒基-2-苯基吲哚；EEA1：早期内体抗原 1；FA：甲酸；GFP：绿色荧光蛋白；LAMP2：溶酶体相关膜蛋白 2；MAP1LC3/LC3：微管相关蛋白 1 轻链 3；MAP2：微管相关蛋白 2；nmAβ：未修饰的淀粉样-β；npAβ：非磷酸化的淀粉样-β；pAβ：磷酸化的淀粉样-β；p-Ser26Aβ：丝氨酸残基 26 磷酸化的淀粉样-β；p-Ser8Aβ：丝氨酸残基 8 磷酸化的淀粉样-β；RAB：RAS 癌基因家族成员 RAB；RFP：红色荧光蛋白；SQSTM1/p62：自噬体相关蛋白 1；YFP：黄色荧光蛋白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/8c05da9c5b90/KAUP_A_2252300_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/d9414c7678bf/KAUP_A_2252300_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/f7ceabb4ffd1/KAUP_A_2252300_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/a7be00cebc4e/KAUP_A_2252300_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/80e251503a39/KAUP_A_2252300_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/1069711c97c6/KAUP_A_2252300_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/0eeaf0d14df0/KAUP_A_2252300_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/508e23185b8a/KAUP_A_2252300_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/8c05da9c5b90/KAUP_A_2252300_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/d9414c7678bf/KAUP_A_2252300_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/f7ceabb4ffd1/KAUP_A_2252300_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/a7be00cebc4e/KAUP_A_2252300_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/80e251503a39/KAUP_A_2252300_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/1069711c97c6/KAUP_A_2252300_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/0eeaf0d14df0/KAUP_A_2252300_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/508e23185b8a/KAUP_A_2252300_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6390/10761119/8c05da9c5b90/KAUP_A_2252300_F0008_OC.jpg

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