Chen Chuangjiang, Wang Chenlong, Jiang Hui, Wang Mengya, Rahman Sajid Ur, Chen Changjiang, Ding Hongyan, Zhao Chang, Huang Wanyue, Wang Xichun
College of Veterinary Medicine, Anhui Agricultural University, Hefei 230036, China.
School of Public Health and Emergency Management, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China.
Toxins (Basel). 2024 Dec 26;17(1):7. doi: 10.3390/toxins17010007.
Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. Rutin, a natural flavonoid with antioxidant activities, has been studied for its potential involvement in mitigating ZEA-induced apoptosis in porcine endometrial stromal cells (ESCs) and its potential molecular mechanism, particularly concerning the expression of Nrf2. This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. Experimental data reveal that ZEA suppresses Nrf2 nuclear translocation and reduces mitochondrial membrane potential (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), and mitochondrial pathway-driven apoptosis. Notably, rutin mitigates ZEA-induced apoptosis through Nrf2 activation. These findings highlight Nrf2 as a critical factor in rutin's protective effects against ZEA-induced apoptosis, offering valuable insights for the clinical prevention and treatment of ZEA toxicity.
玉米赤霉烯酮（ZEA）是一种常见于发霉谷物中的霉菌毒素，具有一系列毒性作用，严重影响了畜牧业。芦丁是一种具有抗氧化活性的天然黄酮类化合物，其在减轻ZEA诱导的猪子宫内膜基质细胞（ESC）凋亡中的潜在作用及其潜在分子机制，特别是关于Nrf2的表达，已得到研究。本研究调查了芦丁减轻ZEA诱导的ESC凋亡的分子途径，重点关注Nrf2的作用。实验数据表明，ZEA抑制Nrf2核转位并降低线粒体膜电位（MMP），导致氧化应激、内质网应激（ERS）和线粒体途径驱动的凋亡。值得注意的是，芦丁通过激活Nrf2减轻ZEA诱导的凋亡。这些发现突出了Nrf2是芦丁对ZEA诱导的凋亡具有保护作用的关键因素，为ZEA毒性的临床预防和治疗提供了有价值的见解。
