Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan.
Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan.
Neuroreport. 2023 Oct 4;34(15):748-758. doi: 10.1097/WNR.0000000000001950. Epub 2023 Aug 30.
Curcumin, a phenolic pigment, plays an inhibitory role in astrocytes activation which are involved in the pathogenesis of neurological diseases and inflammatory responses. The present study aimed to investigate the underlying regulatory mechanism behind the therapeutic effect of curcumin on the lipopolysaccharide (LPS)-activated astrocytes in vitro. Specifically, we investigated the inhibitory effect of curcumin on LPS-induced astrocyte's proliferation. Additionally, we investigated whether the adenosine-monophosphate-activated protein kinase signaling (AMPK) pathway was involved in this process. Our data demonstrated that curcumin significantly increased the level of phosphorylated AMPK protein in LPS-activated astrocytes. In addition, our data demonstrated that curcumin play an inhibitory role on the migration, autophagy, the pro-inflammatory mediators by the AMPK signaling pathway in LPS-activated astrocytes. These results could shed light on understanding of molecular mechanism for the inhibition of curcumin on migration, autophagy, and the pro-inflammatory mediators during the process of astrocyte activation, and might contribute to a promising therapeutic intervention in the neurological diseases-related astrocytes activation.
姜黄素是一种酚类色素，在星形胶质细胞激活中发挥抑制作用，星形胶质细胞参与神经疾病和炎症反应的发病机制。本研究旨在探讨姜黄素对体外脂多糖（LPS）激活星形胶质细胞的治疗作用的潜在调节机制。具体而言，我们研究了姜黄素对 LPS 诱导的星形胶质细胞增殖的抑制作用。此外，我们还研究了腺苷一磷酸激活蛋白激酶信号通路（AMPK）是否参与了这一过程。我们的数据表明，姜黄素显著增加了 LPS 激活的星形胶质细胞中磷酸化 AMPK 蛋白的水平。此外，我们的数据表明，姜黄素通过 LPS 激活的星形胶质细胞中的 AMPK 信号通路，对迁移、自噬和促炎介质发挥抑制作用。这些结果可能有助于深入了解姜黄素抑制星形胶质细胞激活过程中迁移、自噬和促炎介质的分子机制，并可能为神经疾病相关星形胶质细胞激活的治疗干预提供新的思路。
