Grupo de Neurociencias: Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, UNAM, Mexico.
Grupo de Neurociencias: Laboratorio de Neurogenómica Cognitiva, Unidad de Investigación en Psicobiología y Neurociencias, Coordinación de Psicobiología y Neurociencias, Facultad de Psicología, UNAM, Mexico.
Neurosci Biobehav Rev. 2023 Oct;153:105375. doi: 10.1016/j.neubiorev.2023.105375. Epub 2023 Aug 27.
This narrative review article summarizes the current state of knowledge regarding the relationship between the endocannabinoid system (ECS) and aggression across multiple vertebrate species. Experimental evidence indicates that acute administration of phytocannabinoids, synthetic cannabinoids, and the pharmacological enhancement of endocannabinoid signaling decreases aggressive behavior in several animal models. However, research on the chronic effects of cannabinoids on animal aggression has yielded inconsistent findings, indicating a need for further investigation. Cannabinoid receptors, particularly cannabinoid receptor type 1, appear to be an important part of the endogenous mechanism involved in the dampening of aggressive behavior. Overall, this review underscores the importance of the ECS in regulating aggressive behavior and provides a foundation for future research in this area.
这篇叙述性评论文章总结了目前关于内源性大麻素系统 (ECS) 与多种脊椎动物的攻击性之间关系的知识状况。实验证据表明，植物大麻素、合成大麻素的急性给药以及内源性大麻素信号的药理学增强会降低几种动物模型中的攻击行为。然而，关于大麻素对动物攻击行为的慢性影响的研究产生了不一致的结果，表明需要进一步研究。大麻素受体，特别是大麻素受体 1，似乎是参与抑制攻击行为的内源性机制的重要组成部分。总的来说，这篇综述强调了 ECS 在调节攻击行为中的重要性，并为该领域的未来研究提供了基础。
