血清铜和锌水平在子宫内膜异位症和上皮性卵巢癌诊断评估中的应用。

Use of serum copper and zinc levels in the diagnostic evaluation of endometrioma and epithelial ovarian carcinoma.

出版信息

Ceska Gynekol. 2023;88(4):279-286. doi: 10.48095/cccg2023279.

DOI:10.48095/cccg2023279

Abstract

OBJECTIVE

The aim of this study is to evaluate serum copper (Cu) and zinc (Zn) levels in patients with epithelial ovarian cancer and endometrioma.

MATERIALS AND METHODS

We included 21 epithelial ovarian cancer patients, 47 endometrioma patients, 31 healthy women of reproductive age, and 10 healthy women in menopause. Cu and Zn levels and Cu/Zn ratios were compared.

RESULTS

In the endometrioma group, Cu levels (P = 0.04) and Cu/Zn ratio (P < 0.01) were higher, while Zn levels (P < 0.01) were lower compared to the control group. The threshold value of 1.15 with 62% sensitivity and 61% specificity was calculated for the Cu/Zn ratio using the ROC curve (AUC = 0.688; P = 0.005). In the ovarian cancer group, Cu levels (P ≤ 0.01) and Cu/Zn ratio (P = 0.02) were higher, whereas Zn levels (P ≤ 0.02) were lower compared to the control group. The Cu/Zn ratio threshold value of 1.37 was calculated with 76% sensitivity and 90% specificity (AUC = 0.829; P = 0.004). The Zn level was lower (P = 0.02), and the Cu/Zn ratio was higher (P = 0.01) in the ovarian cancer group compared to the endometrioma group.

CONCLUSION

The threshold value of the Cu/Zn ratio for ovarian cancer could be determined with a specificity of 90%, whereas the sensitivity and specificity of the Cu/Zn ratio for endometrioma were low.

摘要

目的

本研究旨在评估上皮性卵巢癌和子宫内膜异位症患者的血清铜（Cu）和锌（Zn）水平。

材料和方法

我们纳入了 21 例上皮性卵巢癌患者、47 例子宫内膜异位症患者、31 名适龄健康女性和 10 名绝经后健康女性。比较了 Cu 和 Zn 水平以及 Cu/Zn 比值。

结果

在子宫内膜异位症组中，Cu 水平（P = 0.04）和 Cu/Zn 比值（P < 0.01）较高，而 Zn 水平（P < 0.01）较低。使用 ROC 曲线计算 Cu/Zn 比值的截断值为 1.15，其灵敏度为 62%，特异性为 61%（AUC = 0.688；P = 0.005）。在卵巢癌组中，Cu 水平（P ≤ 0.01）和 Cu/Zn 比值（P = 0.02）较高，而 Zn 水平（P ≤ 0.02）较低。计算出 Cu/Zn 比值的截断值为 1.37，其灵敏度为 76%，特异性为 90%（AUC = 0.829；P = 0.004）。与子宫内膜异位症组相比，卵巢癌组的 Zn 水平较低（P = 0.02），Cu/Zn 比值较高（P = 0.01）。