Djoric Jelica, Djinic Krasavcevic Ana, Barac Milena, Kuzmanovic Pficer Jovana, Brkovic Bozidar, Nikolic-Jakoba Natasa
Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Dr Subotica 4, Belgrade, Serbia.
Department of Medical Statistics and Informatics, School of Dental Medicine, University of Belgrade, Dr Subotica 1, Belgrade, Serbia.
Clin Oral Investig. 2023 Oct;27(10):6221-6234. doi: 10.1007/s00784-023-05238-1. Epub 2023 Aug 29.
The primary aim was to assess the pain during intraseptal anesthesia (ISA) administration, as well as during and after scaling and root planing (SRP). The secondary aims pertained to comparing the pain in different jaw regions and evaluating the factors affecting pain during ISA administration, during and after SRP.
ISA was obtained with three different doses of 4% articaine with 1:100,000 epinephrine (4%Ar + Ep) in 360 patients. The pain levels were measured using the visual analogue scales (VAS) for pain intensity during ISA administration (VASa), during SRP (VASi), and after SRP (VASp). These findings were then correlated with periodontal parameters. Regression analysis was performed for pain during ISA, during and after SRP.
Anesthesia administration was painful in 80.8% of cases. VASa negatively correlated with pocket depth (PPD). VASi showed no dose-dependency, except in mandibular premolars. VASi negatively correlated with the clinical attachment level (CAL). VASp positively correlated with PPD and CAL. Positive bleeding on probing reduced the chance of pain during ISA administration. Longer anesthesia duration and wider anesthetic field (orally) increased the prospects of painless SRP.
No dose-dependent differences were found regarding patient discomfort and pain intensity of ISA delivery of 4%Ar + Ep for SRP.
The pain during ISA administration was mild and well tolerated regardless of the anesthetic dose. A lower intensity of pain during SRP can be expected in patients with greater CAL. Post-treatment pain can be anticipated after SRP in the regions with greater PPD and CAL.
NCT04392804 (May 9, 2020).
主要目的是评估在隔区内注射麻醉(ISA)过程中以及龈下刮治和根面平整(SRP)期间及之后的疼痛情况。次要目的包括比较不同颌骨区域的疼痛情况,并评估在ISA注射过程中以及SRP期间和之后影响疼痛的因素。
在360例患者中使用三种不同剂量的含1:100,000肾上腺素的4%阿替卡因(4%Ar + Ep)进行ISA。使用视觉模拟量表(VAS)测量在ISA注射期间(VASa)、SRP期间(VASi)和SRP之后(VASp)的疼痛强度。然后将这些结果与牙周参数相关联。对ISA期间、SRP期间及之后的疼痛进行回归分析。
80.8%的病例在麻醉给药时感到疼痛。VASa与牙周袋深度(PPD)呈负相关。VASi除在下颌前磨牙外无剂量依赖性。VASi与临床附着水平(CAL)呈负相关。VASp与PPD和CAL呈正相关。探诊时阳性出血降低了ISA注射期间疼痛的几率。更长的麻醉持续时间和更宽的麻醉区域(口腔内)增加了无痛SRP的可能性。
对于SRP的4%Ar + Ep的ISA给药,在患者不适和疼痛强度方面未发现剂量依赖性差异。
无论麻醉剂量如何,ISA给药期间的疼痛都很轻微且耐受性良好。CAL较大的患者在SRP期间可预期疼痛强度较低。在PPD和CAL较大的区域,SRP后可预期有治疗后疼痛。
NCT04392804(2020年5月9日)。