去氨加压素对心脏手术后出血的影响：一项叙述性综述。
Effect of Desmopressin on Bleeding After Heart Surgeries: A Narrative Review.
作者信息
Jahangirifard Alireza, Mirtajani Seyed Bashir, Madadi Firoozeh
机构信息
Lung Transplant Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Anesthesiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Anesth Pain Med. 2023 Mar 10;13(2):e133894. doi: 10.5812/aapm-133894. eCollection 2023 Apr.
Desmopressin is an analog of the antidiuretic hormone (vasopressin), which causes anticoagulant activity by increasing plasma factor 8. The use of desmopressin dates back to 1977, when this hormone was used to prevent bleeding during tooth extraction and surgery in patients with hemophilia A and von Willebrand disease. After that, this hormone was expanded to prevent bleeding in congenital defects and conditions such as chronic kidney and liver failure. Also, this hormone is used to prevent bleeding in major surgeries such as heart surgery, where the patient loses much blood and needs a blood transfusion. Considering the importance of desmopressin in bleeding control, the present study was conducted to investigate the possible effect of this hormone in heart surgery.
去氨加压素是抗利尿激素（血管加压素）的类似物，它通过增加血浆因子8来产生抗凝活性。去氨加压素的使用可追溯到1977年，当时这种激素被用于预防甲型血友病和血管性血友病患者拔牙及手术期间的出血。此后，这种激素的应用范围扩大到预防先天性缺陷以及慢性肾和肝功能衰竭等病症中的出血。此外，这种激素还用于心脏手术等大型手术中预防出血，在这类手术中患者会大量失血并需要输血。鉴于去氨加压素在控制出血方面的重要性，本研究旨在探讨这种激素在心脏手术中的可能作用。
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