Orlichenko Anton, Su Kuan-Jui, Tian Qing, Shen Hui, Deng Hong-Wen, Wang Yu-Ping
Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118.
Center for Biomedical Informatics and Genomics, School of Medicine, Tulane University, New Orleans, LA 70118.
ArXiv. 2023 Aug 25:arXiv:2308.07992v2.
Functional magnetic resonance imaging (fMRI) and functional connectivity (FC) have been used to follow aging in both children and older adults. Robust changes have been observed in children, where high connectivity among all brain regions changes to a more modular structure with maturation. In this work, we examine changes in FC in older adults after two years of aging in the UK Biobank longitudinal cohort.
We process data using the Power264 atlas, then test whether FC changes in the 2,722-subject longitudinal cohort are statistically significant using a Bonferroni-corrected t-test. We also compare the ability of Power264 and UKB-provided, ICA-based FC to determine which of a longitudinal scan pair is older.
We find a 6.8% average increase in SMT-VIS connectivity from younger to older scan (from = 0.39 to = 0.42) that occurs in male, female, older subject (> 65 years old), and younger subject (< 55 years old) groups. Among all inter-network connections, this average SMT-VIS connectivity is the best predictor of relative scan age, accurately predicting which scan is older 57% of the time. Using the full FC and a training set of 2,000 subjects, one is able to predict which scan is older 82.5% of the time using either the full Power264 FC or the UKB-provided ICA-based FC.
We conclude that SMT-VIS connectivity increases in the longitudinal cohort, while resting state FC increases generally with age in the cross-sectional cohort. However, we consider the possibility of a change in resting state scanner task between UKB longitudinal data acquisitions.
功能磁共振成像（fMRI）和功能连接性（FC）已被用于追踪儿童和老年人的衰老过程。在儿童中观察到了显著变化，随着成熟，所有脑区之间的高连接性转变为更模块化的结构。在这项研究中，我们在英国生物银行纵向队列中研究了两年衰老后老年人FC的变化。
我们使用Power264图谱处理数据，然后使用Bonferroni校正的t检验来测试2722名受试者纵向队列中的FC变化是否具有统计学意义。我们还比较了Power264和英国生物银行提供的基于独立成分分析（ICA）的FC确定纵向扫描对中哪一个更老的能力。
我们发现从较年轻扫描到较年长扫描，男性、女性、老年受试者（>65岁）和年轻受试者（<55岁）组中，SMT-VIS连接性平均增加了6.8%（从 = 0.39增至 = 0.42）。在所有网络间连接中，这种平均SMT-VIS连接性是相对扫描年龄最好的预测指标，能在57%的时间内准确预测哪次扫描更老。使用完整的FC和2000名受试者的训练集，使用完整的Power264 FC或英国生物银行提供的基于ICA的FC，能够在82.5%的时间内预测哪次扫描更老。
我们得出结论，纵向队列中SMT-VIS连接性增加，而横断面队列中静息态FC通常随年龄增加。然而，我们考虑了英国生物银行纵向数据采集之间静息态扫描仪任务发生变化的可能性。
