停用聚多卡醇硫酸酯钠后双侧卵黄样沉着物迅速消退的罕见病例。
An unusual case of rapid resolution of bilateral vitelliform deposits after discontinuation of pentosan polysulfate sodium.
作者信息
Kalaw Fritz Gerald P, Scott Nathan L, Borooah Shyamanga
机构信息
Jacobs Retina Center, University of California San Diego, La Jolla, CA, 92093, USA.
Viterbi Family Department of Ophthalmology and Shiley Eye Institute, University of California San Diego, La Jolla, CA, 92093, USA.
出版信息
Am J Ophthalmol Case Rep. 2023 Jun 20;32:101875. doi: 10.1016/j.ajoc.2023.101875. eCollection 2023 Dec.
PURPOSE
To report the structural and functional changes in a 67-year-old male with pentosan polysulfate sodium (PPS) maculopathy with a progressive resolution of bilateral vitelliform lesions after PPS cessation.
OBSERVATIONS
The patient was initially seen after taking daily PPS for over 26 years. Three months after discontinuing PPS, the bilateral vitelliform lesions identified on spectral-domain optical coherence tomography (SD-OCT) at initial consultation had completely resolved. Bilateral resolution of vitelliform lesions was associated with a decline in best-corrected visual acuity, and ellipsoid zone disruption on SD-OCT.
CONCLUSIONS AND IMPORTANCE
Several PPS maculopathy phenotypes have been previously described including vitelliform lesions. Our case highlights that discontinuing PPS may lead to rapid resolution of vitelliform lesions in PPS maculopathy and may be associated with a rapid reduction in vision.
目的
报告一名67岁男性戊聚糖多硫酸钠（PPS）黄斑病变患者的结构和功能变化，该患者在停用PPS后双侧卵黄样病变逐渐消退。
观察结果
该患者在每日服用PPS超过26年后首次就诊。停用PPS三个月后，初诊时通过光谱域光学相干断层扫描（SD-OCT）发现的双侧卵黄样病变已完全消退。卵黄样病变的双侧消退与最佳矫正视力下降以及SD-OCT上的椭圆体带破坏有关。
结论与意义
先前已描述了几种PPS黄斑病变表型，包括卵黄样病变。我们的病例强调，停用PPS可能会使PPS黄斑病变中的卵黄样病变迅速消退，并可能与视力迅速下降有关。
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