Hu Honghua, Shklovskaya Elena, Deva Anand, Xu Haiying, Fan Kelly, Brosamer Kristen, Willson Richard, Khan Imran, Sinha Mithun, Kadin Marshall E
Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, Australia.
Departments of Plastic Surgery, Pathology and Laboratory Medicine, Rhode Island Hospital and Brown University Alpert School of Medicine, Providence, Rhode Island, USA.
Am J Hematol. 2023 Nov;98(11):E312-E314. doi: 10.1002/ajh.27055. Epub 2023 Aug 30.
More than 1300 women with breast implants have developed an anaplastic large cell lymphoma (ALCL) in fluid (seroma) around their implant. More often, seromas are due to benign causes, for example, capsule contracture, leakage, or trauma. Our report in American Journal of Hematology identified several cytokines (IL-9, IL-10, IL-13) as significantly elevated only in seromas due to ALCL. We further showed that the most robust biomarker, IL-10, could be detected by a lateral flow assay (similar to COVID detection) within minutes allowing physicians to quickly plan management, eliminate or reduce costly testing and patient time away from family. Early detection of ALCL in seromas before infiltration may avoid need for cytotoxic or immunotherapy and is possibly life-saving.
1300多名接受隆胸植入物的女性在植入物周围的液体（血清肿）中发生了间变性大细胞淋巴瘤（ALCL）。更常见的情况是，血清肿是由良性原因引起的，例如包膜挛缩、渗漏或创伤。我们发表在美国《血液学杂志》上的报告指出，几种细胞因子（IL-9、IL-10、IL-13）仅在由ALCL引起的血清肿中显著升高。我们进一步表明，最可靠的生物标志物IL-10可以通过侧流检测法（类似于新冠检测）在几分钟内检测到，这使医生能够迅速制定治疗方案，省去或减少昂贵的检测以及患者与家人分离的时间。在血清肿浸润前早期检测出ALCL，可能避免使用细胞毒性或免疫疗法，甚至可能挽救生命。
