Joensuu H
Strahlenther Onkol. 1986 Sep;162(9):535-9.
Hospital records of 201 consecutive and histologically diagnosed non-Hodgkin's lymphoma patients were retrospectively analysed in an effort to determine the clinical prognostic factors affecting survival. The uncorrected five-year survival was 45%, and when corrected for other causes of death than lymphoma 48%. Response to the primary treatment (p less than 0.001), stage of the disease at diagnosis (p less than 0.001), occurrence of B-symptoms (p less than 0.01) and age (p less than 0.01) were strongly correlated to the final outcome. B-symptoms had negative effect on survival during the first year after the diagnosis, but not afterwards. Survival decreased with advancing age except in children, who had as poor survival as patients over 60 years of age. The primary site, sex or occurrence of extranodal lymphoma (43%) did not have influence on survival. Patients with a positive bone marrow aspiration biopsy did not have less favourable survival than other patients with stage IV lymphoma. Patients with a positive bipedal lymphangiogram had similar prognosis as those with a negative one. It is concluded that the most important prognostic factors other than histology in non-Hodgkin's lymphomas are response to the primary treatment, stage, age and occurrence of B-symptoms.
对201例经组织学诊断的非霍奇金淋巴瘤患者的医院记录进行回顾性分析，以确定影响生存的临床预后因素。未经校正的五年生存率为45%，校正除淋巴瘤以外的其他死亡原因后为48%。对初始治疗的反应（p<0.001）、诊断时疾病的分期（p<0.001）、B症状的出现（p<0.01）和年龄（p<0.01）与最终结局密切相关。B症状在诊断后的第一年对生存有负面影响，但之后没有。除儿童外，生存随年龄增长而降低，儿童的生存率与60岁以上患者一样低。原发部位、性别或结外淋巴瘤的发生（43%）对生存没有影响。骨髓穿刺活检阳性的患者与其他IV期淋巴瘤患者的生存情况并无差异。双足淋巴管造影阳性的患者与阴性患者的预后相似。结论是非霍奇金淋巴瘤中除组织学外最重要的预后因素是对初始治疗的反应、分期、年龄和B症状的出现。
