[慢性肾小球肾炎临床病程及形态学变化动态的比较评估]
[Comparative evaluation of the clinical course and dynamics of the morphological changes in chronic glomerulonephritis].
作者信息
Tov N L, Valentik M F, Vlazneva V A, Kagalovskaia I M, Nesina I A
出版信息
Ter Arkh. 1986;58(8):10-3.
The results of a simultaneous study of a clinical and morphological course of chronic glomerulonephritis (CGN) in 30 patients after repeated morphological investigation of the renal tissue showed that a prevailing tendency in this disease was the progression of morphological changes which could be noted in a stable clinical picture and even in clinical improvement. The detection of tubulointerstitial changes in the first nephrobiopsy was an unfavorable prognostic factor. Of the greatest importance for indirect assessment of a morphological course of CGN were changes in creatinine clearance, effective renal plasma flow and arterial pressure. A morphological course of different variants of CGN and the effect of pathogenetic therapy on it were analyzed.
对30例慢性肾小球肾炎（CGN）患者的临床和形态学病程进行同步研究，在对肾组织进行反复形态学检查后发现，该疾病的主要趋势是形态学改变的进展，这在稳定的临床症状中甚至在临床症状改善时都可观察到。首次肾活检时检测到肾小管间质改变是一个不良预后因素。对CGN形态学病程进行间接评估最重要的是肌酐清除率、有效肾血浆流量和动脉压的变化。分析了CGN不同变体的形态学病程及其对病因治疗的反应。
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