Siniachenko O V, Diadyk A I, Oberemchenko Ia V, Vasilenko I V, Dikshteĭn E A
Ter Arkh. 1986;58(8):29-32.
Proceeding from the results of a study of 139 patients suffering from primary gout with kidney involvement the authors have defined 4 clinicomorphological types of nephropathy which differed both in their course and prognosis. The I proteinuric type was characterized by early signs of stable proteinuria, sometimes with the development of the nephrotic syndrome in which a morphological study revealed mainly glomerular changes. The II urolithic type was characterized by the appearance of renal colics at the onset of nephropathy, frequently with the passage of concrements (a morphological study revealed mainly tubular and stromal lesions). The III hypertensive type was characterized by the appearance of persistent arterial hypertension (a morphological study revealed mainly vascular and interstitial changes). The IV latent type was characterized by the absence of or a transient urinary syndrome (a morphological study showed mainly interstitial changes). The first signs of renal failure in these types of nephropathy developed, on an average, 7, 15, 11 and 12 years later, the 20-year survival was 24, 92, 68 and 100%, respectively.
根据对139例原发性痛风伴肾脏受累患者的研究结果，作者确定了4种临床形态学类型的肾病，它们在病程和预后方面均有所不同。I型蛋白尿型的特征是早期出现稳定的蛋白尿迹象，有时会发展为肾病综合征，形态学研究显示主要为肾小球改变。II型尿路结石型的特征是肾病发作时出现肾绞痛，常伴有结石排出（形态学研究显示主要为肾小管和间质病变）。III型高血压型的特征是出现持续性动脉高血压（形态学研究显示主要为血管和间质改变）。IV型潜伏型的特征是无或仅有短暂的泌尿系统症状（形态学研究显示主要为间质改变）。这些类型的肾病出现肾衰竭的最初迹象，平均分别在7年、15年、11年和12年后，20年生存率分别为24%、92%、68%和100%。
