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解剖性二尖瓣修复:交界旁区域人工腱索长度的数学预测

Anatomical Mitral Valve Repair: Mathematical Prediction of Artificial Chordae Length in Para-Commissural Regions.

作者信息

Gun Mesut, Barry Misbaou, Tribouilloy Christophe, Bohbot Yohann, Touati Gilles

机构信息

Department of Cardiology, Amiens Picardie University Hospital, Amiens, France.

Department of Cardiac Surgery, Amiens Picardie University Hospital, Amiens, France.

出版信息

Curr Probl Cardiol. 2024 Jan;49(1 Pt A):102063. doi: 10.1016/j.cpcardiol.2023.102063. Epub 2023 Aug 29.

Abstract

To develop a mathematical formula for calculating the length of ruptured mitral valve chordae (with a view to surgically replacing them with artificial chordae) when rupture occurs at scallop A1, A3, P1, or P3. We studied human cadaver hearts collected by the Faculty of Medicine at Amiens Picardy University Hospital. The donors' mean age standard deviation age at death was 79 ± 10. After weighing and dissection, we counted the number of para-commissural chordae per scallop and measured their length with a digital calliper. A total of 31 human cadaver hearts (14 from females and 17 from males) were analyzed. The mean lengths of scallops A1, A2, A3, P1, P2, and P3 were 17.45, 19.42, 17.58, 13.32, 14.52, and 13.26 mm, respectively. A linear regression gave the following mathematical equations: A1 = 0.96 × A2- - 1.3 (R: 0.99; P < 0.001); A3 = 0.9 × A2 + 0.17 (R: 0.95; P < 0.01); P1 = 0.87 × P2 +0.74 (R: 0.89; P < 0.001), and P3 = 0.91 × P2 - 0.01 (R: 0.87; P < 0.0001). When the patient's anatomy prevents manual measurements of the chordae during mitral valve repair surgery, the mathematical formulae derived here can be used to predict the length of the chordae on A1, A3, P1, and P3 from the length of the chordae on A2 and P2. The mitral chordae can therefore be replaced with prostheses with a great degree of precision.

摘要

为了推导一个数学公式,用于计算二尖瓣腱索在A1、A3、P1或P3区发生断裂时的长度(以便用人工腱索进行手术替换)。我们研究了亚眠皮卡第大学医院医学院收集的人体尸体心脏。捐赠者死亡时的平均年龄标准差为79±10岁。称重和解剖后,我们计算每个扇区的瓣周腱索数量,并用数字卡尺测量其长度。共分析了31颗人体尸体心脏(14颗来自女性,17颗来自男性)。A1、A2、A3、P1、P2和P3扇区的平均长度分别为17.45、19.42、17.58、13.32、14.52和13.26毫米。线性回归得出以下数学方程:A1 = 0.96×A2 - 1.3(R:0.99;P < 0.001);A3 = 0.9×A2 + 0.17(R:0.95;P < 0.01);P1 = 0.87×P2 + 0.74(R:0.89;P < 0.001),P3 = 0.91×P2 - 0.01(R:0.87;P < 0.0001)。当患者的解剖结构在二尖瓣修复手术期间妨碍对腱索进行手动测量时,此处推导的数学公式可用于根据A2和P2区腱索的长度预测A1、A3、P1和P3区腱索的长度。因此,可以非常精确地用假体替换二尖瓣腱索。

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