van Gend H W, Brinkman M B, Mol H, Kommerij R, van der Kreek F W
Tijdschr Diergeneeskd. 1986 Oct 1;111(19):911-20.
Dapsone is frequently used as a bacteriostatic drug in the treatment of mastitis, endometritis and footrot (necrotic pododermatitis). The farmer usually obtains this drug by 'non-ethical' channels. A regular scheme of checking the milk for residues of sulphonamides will be introduced in 1986. The sensitivity of the test is approximately 25 ppb for Dapsone. This will result in lower milk price in the case of positive tests. In healthy animals, it is shown that intramuscular treatment with 35 grammes (+/- 70 mg/kg-1 body weight) of Dapsone results in residues of Dapsone and its metabolite monoacetyldapsone above this detection level for more than 6 1/2 days. Within 5 days after oral treatment with 48.75 grammes (+/- 100 mg/kg-1 body weight) and 2 1/2 days after single intramammary treatment with 0.8 grammes, the concentrations of residues detected dropped below 25 ppb. The other well-known metabolite diacetyldapsone was only present in detectable quantities in the first milkings after oral treatment.
氨苯砜常用于治疗乳腺炎、子宫内膜炎和腐蹄病（坏死性足皮炎）的抑菌药物。养殖户通常通过“不正规”渠道获取此药。1986年将推行一项常规计划，检测牛奶中磺胺类药物残留。该检测对氨苯砜的灵敏度约为25 ppb。检测呈阳性时牛奶价格会降低。在健康动物身上发现，肌肉注射35克（±70毫克/千克体重）氨苯砜会使氨苯砜及其代谢产物单乙酰氨苯砜的残留量在6.5天以上高于此检测水平。口服48.75克（±100毫克/千克体重）后5天内，以及单次乳房内注射0.8克后2.5天内，检测到的残留浓度降至25 ppb以下。另一种知名代谢产物双乙酰氨苯砜仅在口服治疗后的首次挤奶中可检测到。
