George M E, Andersen M E
Toxicol Appl Pharmacol. 1986 Sep 15;85(2):169-80. doi: 10.1016/0041-008x(86)90110-9.
Nonadecafluoro-n-decanoic acid (ND-FDA) has a single dose ip LD50 of 41 mg/kg and causes anorexia and a wasting syndrome. NDFDA also appears to affect lipid metabolism although the metabolic fate and mechanism of action are not known. Control rats were pair fed with rats given 50 mg/kg. Body weights and food consumption were measured daily; body and organ weights, tissue histopathology, and hematological and clinical chemistry parameters were determined at 4, 8, 12, 16, and 30 days postdosing. Liver samples were obtained for determining cholesterol, cholesterol esters, phospholipids, total lipids, fatty acid ratios, and NDFDA. The rats became anorectic within 4 days and did not resume feeding for 10-12 days, losing about 40% of their body weight. There was a decrease in serum protein; total liver protein decreased and there was an increase in measured fatty acids except for stearic. Liver to body weight ratios of dosed rats were twice those of control rats since absolute liver weights in dosed rats remained constant during the weight loss period. The most striking histopathological change was seen in the liver with a uniform persistent cellular swelling at all times. Separation of the lipids by thin layer chromatography indicated that NDFDA was present in the most polar fraction. There also were fatty changes in the proximal tubular epithelium of the kidneys.
十九氟正癸酸（ND - FDA）的腹腔注射半数致死剂量（LD50）为41毫克/千克，可导致厌食和消瘦综合征。尽管其代谢归宿和作用机制尚不清楚，但ND - FDA似乎也会影响脂质代谢。将对照大鼠与给予50毫克/千克剂量的大鼠进行配对饲养。每天测量体重和食物摄入量；在给药后第4、8、12、16和30天测定体重、器官重量、组织组织病理学以及血液学和临床化学参数。获取肝脏样本以测定胆固醇、胆固醇酯、磷脂、总脂质、脂肪酸比例和ND - FDA。大鼠在4天内出现厌食，10 - 12天内不再进食，体重减轻约40%。血清蛋白减少；肝脏总蛋白减少，除硬脂酸外，所测脂肪酸增加。给药大鼠的肝体重比是对照大鼠的两倍，因为给药大鼠的绝对肝脏重量在体重减轻期间保持恒定。最显著的组织病理学变化出现在肝脏，始终存在均匀持续的细胞肿胀。通过薄层色谱法分离脂质表明，ND - FDA存在于极性最强的部分。肾脏近端肾小管上皮也出现了脂肪变性。
