Kolluri S, Heros R C, Hedley-Whyte E T, Vonsattel J P, Miller D, Zervas N T
Stroke. 1986 Sep-Oct;17(5):976-80. doi: 10.1161/01.str.17.5.976.
Twenty-four cats had an intravenous infusion of either Fluosol or saline and then were subjected to 2 hours of middle cerebral artery occlusion. All the animals infused with Fluosol and one-half the animals infused with saline were ventilated with 100% O2. Tissue oxygen availability and regional cerebral blood flow were measured by platinum electrodes using direct voltage recordings for oxygen measurements and hydrogen clearance curves for measurements of cerebral blood flow. With 100% oxygenation tissue oxygen availability increased significantly in the Fluosol treated animals, however, during the time of ischemia oxygen availability decreased below baseline values to about an equal level whether the animals were treated with Fluosol or saline. Regional cerebral blood flow fell to a similar value in all groups during the time of occlusion. One hour after reperfusion blood flow increased considerably above baseline values in all groups and oxygen availability also increased in all groups but particularly in the Fluosol treated animals. Overall mortality and the size of infarction 1 week after the ischemic insult were not significantly different in the three groups. Mortality was directly related to the size of the infarct which, in turn, was related to the degree of ischemia during the time of occlusion.
24只猫分别静脉输注氟碳化合物或生理盐水，然后进行2小时的大脑中动脉闭塞。所有输注氟碳化合物的动物和一半输注生理盐水的动物用100%氧气通气。使用铂电极通过直接电压记录测量组织氧供，并通过氢清除曲线测量脑血流量以进行氧测量。在100%氧合情况下，氟碳化合物治疗的动物组织氧供显著增加，然而，在缺血期间，无论动物接受氟碳化合物还是生理盐水治疗，氧供都降至基线值以下，达到大致相同的水平。在闭塞期间，所有组的局部脑血流量都降至相似的值。再灌注1小时后，所有组的血流量均显著高于基线值，所有组的氧供也增加，但在氟碳化合物治疗的动物中尤其明显。三组在缺血损伤1周后的总体死亡率和梗死面积无显著差异。死亡率与梗死面积直接相关，而梗死面积又与闭塞期间的缺血程度相关。
