Guo Haoran, Zhang Xiangyu, Li Hui, Fu Chuhan, Jiang Ling, Hu Yibo, Huang Jinhua, Chen Jing, Zeng Qinghai
Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha 410013, China.
Department of Pulmonary and Critical Care Medicine, Third Xiangya Hospital of Central South University, Changsha 410013, China.
iScience. 2023 Aug 9;26(9):107559. doi: 10.1016/j.isci.2023.107559. eCollection 2023 Sep 15.
Fractional CO laser, as a typical ablative laser, has been used to assist in the treatment of many skin diseases, such as photoaging, atrophic scar, hypertrophic scar, superficial pigmentation, vitiligo, and so on. However, the dynamic changes in skin function after fractional CO laser treatment are still unclear. This study explored the changes in local skin function and possible regulatory mechanisms after fractional CO laser treatment for 1, 3, 5, and 7 days through transcriptome high-throughput sequencing. The results showed that fractional CO laser tended to transform the "lesions" into "normal skin", regulate the skin barrier, coordinate the rearrangement of collagen, enhance the local microvascular circulation, activate the immune system to secrete a large number of cytokines, and act as an auxiliary tool to assist drug transport. In conclusion, according to the basic principle of destruction before reconstruction, fractional CO laser plays a key role of balancer in skin reconstruction.
剥脱性二氧化碳激光作为一种典型的剥脱性激光，已被用于辅助治疗多种皮肤疾病，如光老化、萎缩性瘢痕、增生性瘢痕、浅表色素沉着、白癜风等。然而，剥脱性二氧化碳激光治疗后皮肤功能的动态变化仍不清楚。本研究通过转录组高通量测序，探讨了剥脱性二氧化碳激光治疗1、3、5和7天后局部皮肤功能的变化及可能的调节机制。结果表明，剥脱性二氧化碳激光倾向于将“病变”转化为“正常皮肤”，调节皮肤屏障，协调胶原蛋白重排，增强局部微血管循环，激活免疫系统分泌大量细胞因子，并作为辅助工具协助药物转运。总之，根据先破坏后重建的基本原则，剥脱性二氧化碳激光在皮肤重建中起着关键的平衡作用。
Zotero 插件
