Ryu Hye Guk, Park Jinyoung, Kim Hyemin, Kim Wanil, Lee Hwa-Rim, Ko Jeongah, Cho Sung Bin
Clinical Development Team, Cynosure Lutronic Corporation, Goyang, Korea.
Department of Biochemistry and Institute of Medical Science, School of Medicine, Gyeongsang National University, Jinju, Korea.
Clin Cosmet Investig Dermatol. 2025 Aug 7;18:1901-1907. doi: 10.2147/CCID.S534637. eCollection 2025.
Fractional carbon dioxide (CO) lasers are commonly used in dermatological resurfacing, offering precise ablation and controlled dermal remodeling. Although clinical outcomes vary with the energy and pulse settings, comparative morphometric and histometric data on power-dependent tissue interactions are limited.
To evaluate and compare fractional CO laser-induced microscopic thermal zones (MTZs) ablation characteristics at peak powers of 30 W and 40 W using an ex vivo porcine skin model.
Ex vivo porcine skin was treated with a fractional CO laser at energy levels ranging from 40 to 240 mJ under 30 W and 40 W settings. Frozen tissue was used for dermoscopic assessment of ablation diameters, while unfrozen tissue at physiological temperature (30-32°C) was analyzed histologically for ablation depth. Morphometric and histometric measurements were performed and statistically analyzed.
The 30 W and 40 W settings demonstrated energy-dependent increases in ablation depth and diameter. The 40 W laser consistently generated deeper ablation columns (average 11.8% deeper) with narrower surface diameters (average 7.3% narrower) and reduced peripheral carbonization. Linear regression showed strong correlations between energy and ablation depth (r > 0.91) and diameter (r > 0.91), with higher slope coefficients in the 40 W group, indicating greater ablation efficiency.
The 40 W fractional CO laser system offers enhanced precision, deeper dermal penetration, and reduced thermal diffusion compared with the 30 W, despite delivering equivalent total energy. These findings suggest that higher peak power settings may improve fractional resurfacing procedures' safety and clinical outcomes, particularly in populations with darker skin phototypes.
二氧化碳（CO₂）分次激光常用于皮肤磨削术，可实现精确消融和可控的真皮重塑。尽管临床结果会因能量和脉冲设置而有所不同，但关于功率依赖性组织相互作用的比较形态学和组织计量学数据有限。
使用离体猪皮模型评估和比较30 W和40 W峰值功率下二氧化碳分次激光诱导的微观热区（MTZs）消融特征。
在30 W和40 W设置下，使用二氧化碳分次激光以40至240 mJ的能量水平处理离体猪皮。冷冻组织用于通过皮肤镜评估消融直径，而生理温度（30 - 32°C）下的未冷冻组织则进行组织学分析以确定消融深度。进行形态学和组织计量学测量并进行统计分析。
30 W和40 W设置下，消融深度和直径均随能量增加。40 W激光始终产生更深的消融柱（平均深11.8%），表面直径更窄（平均窄7.3%），且周边碳化减少。线性回归显示能量与消融深度（r > 0.91）和直径（r > 0.91）之间存在强相关性，40 W组的斜率系数更高，表明消融效率更高。
与30 W相比，40 W二氧化碳分次激光系统提供了更高的精度、更深的真皮穿透以及更低的热扩散，尽管总能量相当。这些发现表明，更高的峰值功率设置可能会改善分次皮肤磨削术的安全性和临床结果，特别是在皮肤光型较深的人群中。
