Fujishima M, Ibayashi S, Fujii K, Yao H, Sadoshima S
Stroke. 1986 Sep-Oct;17(5):985-8. doi: 10.1161/01.str.17.5.985.
Cerebral blood flows (CBF) were measured in the parietal cortex, the thalamus and the cerebellum by the hydrogen clearance technique in anesthetized spontaneously hypertensive rats, of which hypertension was treated for 16 weeks (long-term) or 8 weeks (short-term) with antihypertensive agents of hydralazine and guanethidine. As compared to non-treated control animals, CBF in the three regions were significantly increased while the calculated cerebrovascular resistances (CVR) were decreased in hypertension-treated animals. Such CBF and CVR changes were greater in SHR with long-term than short-term therapy. Both an increase in CBF and a decrease in CVR were closely related to a fall in the blood pressure. From the present results, it was concluded that earlier and longer treatment of hypertension could lessen or even prevent the increased CVR due to the hypertensive vascular changes, and increase CBF as a result.
采用氢清除技术，在麻醉的自发性高血压大鼠的顶叶皮质、丘脑和小脑中测量脑血流量（CBF）。这些大鼠的高血压分别用肼屈嗪和胍乙啶进行了16周（长期）或8周（短期）的治疗。与未治疗的对照动物相比，经高血压治疗的动物三个区域的CBF显著增加，而计算出的脑血管阻力（CVR）降低。长期治疗的SHR中，这种CBF和CVR的变化比短期治疗更大。CBF的增加和CVR的降低均与血压下降密切相关。从目前的结果可以得出结论，早期和长期治疗高血压可以减轻甚至预防由于高血压血管变化导致的CVR增加，并因此增加CBF。
