Koźniewska E
Department of Clinical and Applied Physiology, Institute of Physiological Sciences, School of Medicine, Warsaw, Poland.
Experientia. 1988 Mar 15;44(3):221-2. doi: 10.1007/BF01941712.
Cerebral blood flow (CBF) was measured and cerebrovascular resistance (CVR) was calculated in anesthetized spontaneously hypertensive rats (SHR) and normotensive rats (NR) following the administration of incremental dosages of i.v. flunarizine or papaverine. CBF and CVR changes following papaverine were the same in both groups of rats irrespective of the dose of the drug. The effect of flunarizine was much more pronounced in SHR than in NR. The results point out the greater dependency of basal cerebrovascular tone in SHR upon Ca2+ influx into vascular smooth muscle cells.
在麻醉的自发性高血压大鼠（SHR）和正常血压大鼠（NR）中，静脉注射递增剂量的氟桂利嗪或罂粟碱后，测量脑血流量（CBF）并计算脑血管阻力（CVR）。两组大鼠罂粟碱给药后的CBF和CVR变化相同，与药物剂量无关。氟桂利嗪对SHR的作用比NR更明显。结果表明，SHR的基础脑血管张力对Ca2+流入血管平滑肌细胞的依赖性更强。
