Chandrasingh Sindhulina, George Carolin E, Inbaraj Leeberk R, Maddipati Tatarao
Department of Microbiology, Bangalore Baptist Hospital, Bengaluru, Karnataka, India.
Division of Community Health and Family Medicine, Bangalore Baptist Hospital, Bengaluru, Karnataka, India.
J Family Med Prim Care. 2023 Jul;12(7):1298-1302. doi: 10.4103/jfmpc.jfmpc_1809_22. Epub 2023 Jul 14.
Assessment of antibody response to vaccination against SARS CoV2 has clinical, public health, and policy implications during the pandemic and in the context of future waves.
In this repeated cross-sectional study, we estimated total binding antibody levels to the spike protein of the SARS CoV2 virus post two doses of Covishield vaccine among 133 health care workers (HCWs) (phase 1), followed by antibody levels among a subset ( = 61) of this group at 9 months after the second dose (phase 2). The time period of the first and second blood collection corresponds to Delta and Omicron waves, respectively.
We report 100% seroconversion post 28 days of the second dose of the Covishield vaccine among infection naïve HCWs. In this study, 33% had a breakthrough infection in phase 1 and 24% reported a history of infection in phase 2. The antibody titres were higher in the breakthrough infection group compared to the infection naïve group during both Delta and Omicron waves.
This shows that there is a good seroconversion with two doses of vaccine, weaning of antibody with time, and a rise of antibody titre if infected with SARS CoV 2 subsequently.
在大流行期间以及未来疫情浪潮的背景下，评估针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）疫苗接种的抗体反应具有临床、公共卫生和政策意义。
在这项重复横断面研究中，我们估计了133名医护人员（HCW）在接种两剂Covishield疫苗后针对SARS-CoV-2病毒刺突蛋白的总结合抗体水平（第1阶段），随后在第二剂接种9个月后对该组中的一个子集（n = 61）进行了抗体水平检测（第2阶段）。第一次和第二次采血的时间段分别对应于德尔塔和奥密克戎浪潮。
我们报告在未感染过的医护人员中，第二剂Covishield疫苗接种28天后血清转化率为100%。在本研究中，33%的人在第1阶段发生了突破性感染，24%的人在第2阶段报告有感染史。在德尔塔和奥密克戎浪潮期间，突破性感染组的抗体滴度均高于未感染组。
这表明两剂疫苗接种后血清转化率良好，抗体随时间下降，而如果随后感染SARS-CoV-2，抗体滴度会上升。
