Zhang C F, Gao Y, Qin Y, Hu X Y, Lu J N, Zhao S J, Lin W C, Liu Y F, Yin G Q, Jiang W H, Fan H F, Deng L
Department of Pediatric Respiratory Medicine, Guangzhou Women and Children's Medical Center, Guangzhou 510120, China.
Zhonghua Er Ke Za Zhi. 2023 Sep 2;61(9):820-826. doi: 10.3760/cma.j.cn112140-20230222-00123.
To compare the effects of the China Children's Asthma Action Plan (CCAAP)-based remote joint management model with traditional management model on the control of childhood asthma. A retrospective cohort study was conducted to analyze the general data and asthma control assessment data of 219 children with asthma who attended the respiratory department of Guangzhou Women's and Children's Medical Center from April 2021 to October 2021 and were followed up for 1 year or more. According to the follow-up management model, the CCAAP-based remote joint management model was used in the observation group and the traditional management model was used in the control group, and the propensity score matching method was applied to match the data of children in the two management models for comparison. Paired-samples -test, Wilcoxon signed-rank test, McNemar -test or -test or nonparametric tests were used to compare the general data and asthma control assessment data between the two matched groups of children. Among 219 children with asthma, 145 were male and 74 were female, aged at consultation (7.2±2.4) years. There were 147 cases in the observation group and 72 cases in the control group, and 27 cases in each of the observation and control groups were successfully matched. The number of asthma exacerbation aura, acute exacerbations, and emergency room visits or hospitalizations for asthma exacerbations were lower in the observation group than in the control group after pairing (1 (0, 2) 3 (1, 5) times, 0 (0,0) 0 (0, 1) times, 0 (0,0) 1 (0, 1) times, =-3.42, -2.58, -3.17, all <0.05). The use of peak flowmeters was higher in children aged 5 years and older in the observation group than in the control group after pairing (100% (22/22) 13% (3/23), =54.00,<0.001). The ratio of actual to predicted 1st second expiratory volume of force after follow-up in the observation group after pairing was higher than that before follow-up in the observation group and after follow-up in the control group ((95±11)% (85±10)%, (95±11)% (88±11)%, =-3.40, 2.25, all <0.05). The rate of complete asthma control after follow-up was higher in both the observation and control groups after pairing than before follow-up for 12 months in both groups (93% (25/27) 41% (11/27), 52% (14/27) 41% (11/27), =56.19, 45.37, both <0.001), and the rate of complete control of asthma in children in the observation group was higher than that in the control group at 3 and 12 months of follow-up management (56% (15/27) 25% (5/20), 93% (25/27) 52% (14/27), =47.00, 54.00, both <0.001). The number of offline follow-up visits, inhaled hormone medication adherence scores, and caregiver's asthma perception questionnaire scores were higher in the observation group than in the control group after pairing (6 (4, 8) 4 (2,5), (4.8±0.3) (4.0±0.6) score, (19.3±2.6) (15.2±2.7) score, =6.58, =6.57, 5.61, all <0.05), and the children in the observation group had lower school absences, caregiver absences, asthma attack visit costs, and caregiver PTSD scores than the control group (0 (0,0) 3 (0, 15) d, 0 (0,0) 3 (0, 10) d, 1 100 (0, 3 700) 5 000 (1 000, 10 000) yuan, 1.3 (1.1, 1.9) 2.0 (1.2, 2.7) score, =-2.89, -2.30, 2.74, 2.73, all <0.05). The CCAAP-based joint management model of asthma control is superior to the traditional management model in the following aspects: it can effectively improve asthma control, self-monitoring, and lung function in children; it can improve treatment adherence and caregivers' asthma awareness; and it can reduce the duration of absenteeism from school, the cost of asthma exacerbation visits, and caregiver's negative psychology.
比较基于中国儿童哮喘行动计划(CCAAP)的远程联合管理模式与传统管理模式对儿童哮喘控制的效果。进行一项回顾性队列研究,分析2021年4月至2021年10月在广州妇女儿童医疗中心呼吸科就诊且随访1年及以上的219例哮喘儿童的一般资料和哮喘控制评估数据。根据随访管理模式,观察组采用基于CCAAP的远程联合管理模式,对照组采用传统管理模式,并应用倾向得分匹配法对两组管理模式下儿童的数据进行匹配比较。采用配对样本t检验、Wilcoxon符号秩检验、McNemar检验或χ²检验或非参数检验比较两组匹配儿童的一般资料和哮喘控制评估数据。219例哮喘儿童中,男性145例,女性74例,就诊时年龄(7.2±2.4)岁。观察组147例,对照组72例,观察组和对照组各成功匹配27例。配对后,观察组哮喘加重先兆、急性加重次数以及哮喘加重急诊就诊或住院次数均低于对照组(1(0,2)次对3(1,5)次,0(0,0)次对0(0,1)次,0(0,0)次对1(0,1)次,t=-3.42,Z=-2.58,Z=-3.17,均P<0.05)。配对后,观察组5岁及以上儿童使用峰流速仪的比例高于对照组(100%(22/22)对13%(3/23),Z=54.00,P<0.001)。配对后,观察组随访后第1秒用力呼气容积实测值与预测值之比高于观察组随访前及对照组随访后((95±11)%对(85±10)%,(95±11)%对(88±11)%,t=-3.40,t=2.25,均P<0.05)。配对后,观察组和对照组随访后完全哮喘控制率均高于两组随访12个月前(93%(25/27)对41%(11/27),52%(14/27)对41%(11/27),Z=56.19,Z=45.37,均P<0.001),且随访管理3个月和12个月时观察组儿童哮喘完全控制率高于对照组(56%(15/27)对25%(5/20),93%(25/27)对52%(14/27),Z=47.00,Z=54.00,均P<0.001)。配对后,观察组线下随访次数、吸入激素用药依从性得分及照顾者哮喘认知问卷得分均高于对照组(6(4,8)次对4(2,5)次,(4.8±0.3)分对(4.0±0.6)分,(19.3±2.6)分对(15.2±2.7)分,Z=6.58,t=6.57,t=5.61,均P<0.05),且观察组儿童缺课天数、照顾者缺勤天数、哮喘发作就诊费用及照顾者创伤后应激障碍得分均低于对照组(0(0,0)天对3(0,15)天,0(0,0)天对3(0,10)天,1100(0,3700)元对5000(1000,10000)元,1.3(1.1,1.9)分对2.0(1.2,2.7)分,Z=-2.89,Z=-2.30,t=2.74,t=2.73,均P<0.05)。基于CCAAP的哮喘联合管理模式在以下方面优于传统管理模式:能有效改善儿童哮喘控制、自我监测及肺功能;能提高治疗依从性及照顾者哮喘认知;能减少缺课天数、哮喘加重就诊费用及照顾者负面心理。