State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Frontier Innovation Center for Dental Medicine Plus, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Oral Dis. 2024 May;30(4):1828-1842. doi: 10.1111/odi.14726. Epub 2023 Aug 31.
The purpose of the systematic review is to verify the presence of PANoptosis in periodontitis based on the published literatures studying cell death in periodontitis.
We conducted a comprehensive review of literature studying the types of cell death in vitro cellular experiments, in vivo rodent studies and clinical studies from three major databases: PubMed, Scopus, and Web of Science. The present systematic review was recorded in the PROSPERO database, under registration number CRD42022383456.
In total, 51 articles were included in this study. Our analysis of in vitro cell models revealed that pyroptosis, necroptosis, and apoptosis could be induced by periodontal pathogens in macrophages, fibroblasts, stem cells, and periodontal ligament cells. Furthermore, three types of cell death were detected in in vivo rodent periodontitis models. Clinical studies on human periodontitis tissue specimens and gingival crevicular fluid (GCF) showed that some key proteins related to pyroptosis, necroptosis, and apoptosis were elevated in periodontitis.
Various studies have established similar in vivo and in vitro models with three modes of death detected under the same conditions, revealing complex interactions between different types of cell death pathways in periodontitis and the potential for PANoptosis to occur in periodontitis.
本系统评价旨在通过研究牙周炎中细胞死亡的文献，验证牙周炎中是否存在 PANoptosis。
我们从三个主要数据库（PubMed、Scopus 和 Web of Science）全面检索了体外细胞实验、体内啮齿动物研究和临床研究中研究细胞死亡类型的文献。本系统评价按照 PROSPERO 数据库（注册号 CRD42022383456）进行记录。
共有 51 篇文章纳入本研究。我们对体外细胞模型的分析表明，牙周致病菌可诱导巨噬细胞、成纤维细胞、干细胞和牙周膜细胞发生细胞焦亡、坏死性凋亡和细胞凋亡。此外，在体内牙周炎啮齿动物模型中检测到了三种类型的细胞死亡。对人牙周炎组织标本和龈沟液（gingival crevicular fluid，GCF）的临床研究表明，牙周炎中细胞焦亡、坏死性凋亡和细胞凋亡相关的一些关键蛋白水平升高。
各种研究均建立了类似的体内和体外模型，在相同条件下检测到三种死亡模式，揭示了牙周炎中不同类型细胞死亡途径之间的复杂相互作用以及 PANoptosis 在牙周炎中发生的可能性。
