Aga Odd-Olav, Bolstad Anne Isine, Lie Stein Atle, Svanes Fevang Bjørg-Tilde
Faculty of Medicine, University of Bergen, Bergen, Norway.
Department of Clinical Dentistry, The Faculty of Medicine, University of Bergen, Bergen, Norway.
Eur J Oral Sci. 2023 Oct-Nov;131(5-6):e12950. doi: 10.1111/eos.12950. Epub 2023 Aug 31.
The aim of this study was to compare the occurrence of periodontitis in patients with primary Sjögren's syndrome (pSS) and a non-Sjögren's patient group during a 7-year period from 2011 through 2017. In this population-based study, the patients were identified based on the International Classification of Diseases-10 (ICD-10) codes registered in the Norwegian Patient Registry (NPR), which contains information on diagnosis and time of admission for all hospitalized patients in Norway. The pSS group comprised patients with ≥4 registrations with ICD-10 code M35.0 (Sjögren's syndrome) as the main diagnosis. The dependent variable was periodontitis, defined by procedure codes registered in the Norwegian Control and Payment of Health Reimbursement (KUHR). Logistic regression analyses estimated the odds ratio for periodontitis in pSS patients relative to non-pSS patients, adjusted for relevant covariates. Lastly, regression analyses were performed separately for each of the 6 age categories. In total, 760 (7.5%) patients in the pSS group and 22,178 (7.1%) in the non-pSS group had periodontitis. When adjusting for covariates, the presence of pSS had no association with periodontitis (OR = 1.06, 95% CI: 0.98-1.14).
本研究的目的是比较2011年至2017年这7年间原发性干燥综合征（pSS）患者与非干燥综合征患者组中牙周炎的发生率。在这项基于人群的研究中，根据挪威患者登记处（NPR）登记的国际疾病分类第10版（ICD-10）编码来确定患者，该登记处包含挪威所有住院患者的诊断和入院时间信息。pSS组包括以ICD-10编码M35.0（干燥综合征）作为主要诊断且登记次数≥4次的患者。因变量是牙周炎，由挪威医疗费用控制与支付系统（KUHR）登记中的程序编码定义。逻辑回归分析估计了pSS患者相对于非pSS患者患牙周炎的比值比，并对相关协变量进行了调整。最后，对6个年龄组分别进行了回归分析。pSS组共有760名（7.5%）患者患有牙周炎，非pSS组有22178名（7. 1%）患者患有牙周炎。在对协变量进行调整后，pSS的存在与牙周炎无关联（比值比=1.06，95%置信区间：0.98-1.14）。
