Wuxi Maternal & Child Health Hospital, Wuxi Medical Center of Nanjing Medical University, Wuxi, 214023, Jiangsu, China.
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214023, Jiangsu, China.
Biomark Med. 2023 May;17(10):509-521. doi: 10.2217/bmm-2023-0190. Epub 2023 Aug 31.
Intrahepatic cholestasis of pregnancy (ICP) is a disease specific to pregnancy, featuring maternal itching and elevated serum bile acid levels. It leads to a series of adverse pregnancy outcomes as well as increased fetal mortality. Routine biochemical markers fail to fulfill the tremendous clinical requirements, thereby novel effective biomarkers are urgently desired. In our review, the potential novel biomarkers for ICP diagnosis are classified into four categories and elaborated in detail. The concrete diagnostic performances (sensitivity, specificity and area under the curve) of these biomarkers are demonstrated in tables. Moreover, the relationships between some biomarkers and ICP pathogenesis are briefly expounded. Nevertheless, only a few novel biomarkers are ideal, and their clinical applicability requires more evidence from larger multicenter trials.
妊娠肝内胆汁淤积症（ICP）是一种妊娠特有的疾病，其特征是母体瘙痒和血清胆汁酸水平升高。它会导致一系列不良的妊娠结局，增加胎儿死亡率。常规生化标志物无法满足巨大的临床需求，因此急需新型有效的生物标志物。在我们的综述中，将 ICP 诊断的潜在新型生物标志物分为四类，并进行了详细阐述。这些生物标志物的具体诊断性能（敏感性、特异性和曲线下面积）在表中进行了展示。此外，还简要阐述了一些生物标志物与 ICP 发病机制之间的关系。然而，只有少数新型生物标志物是理想的，它们的临床适用性需要更多来自更大规模多中心试验的证据。
