Department of Dermatology, Shaanxi Provincial People's Hospital, The Third Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, People's Republic of China.
Department of Dermatology, 72nd Group Army Hospital of PLA, Huzhou, Zhejiang, People's Republic of China.
Arch Dermatol Res. 2023 Dec;315(10):2871-2876. doi: 10.1007/s00403-023-02706-2. Epub 2023 Aug 31.
About 20% of world population suffer from acute urticaria at some stage in their lives. Recent studies showed coagulation dysfunction in chronic urticaria. The involvement of coagulation changes in acute urticaria remains unclear. Fifty-eight acute urticaria patients were enrolled in this study and divided into two groups (referred to throughout as infection-related and infection-unrelated acute urticaria). The routine laboratory parameters including coagulation tests between the two groups were compared. The correlation between coagulation tests and CRP at acute phase was also assessed. Dynamic change of routine coagulation test results at acute phase and resolving phase was compared. The potential performance of coagulation for infection indication was tested. We found D-dimer, fibrin degradation product (FDP), and fibrinogen (Fg) increased in the acute phase of infection-related acute urticaria patients. D-dimer, FDP, Fg, and APTT are positively correlated with CRP in the acute phase. D-dimer and FDP decreased in the resolving phase of infection-related acute urticaria patients. Higher D-dimer (> 0.48 mg/L) and FDP (> 3.84 mg/L) may indicate infection-related acute urticaria. In conclusion, in acute urticaria with low venous thromboembolism risk, D-dimer level and dynamic change can be potentially used for the infection-related clinical practice management.
约 20%的世界人口在其一生中的某个阶段会患有急性荨麻疹。最近的研究表明慢性荨麻疹存在凝血功能障碍。急性荨麻疹中凝血变化的参与情况尚不清楚。本研究纳入了 58 例急性荨麻疹患者，并将其分为两组（分别称为感染相关和非感染相关急性荨麻疹）。比较了两组之间的常规实验室参数，包括凝血试验。还评估了凝血试验与急性期 CRP 的相关性。比较了急性期和缓解期常规凝血试验结果的动态变化。测试了凝血对感染指示的潜在性能。我们发现感染相关急性荨麻疹患者的急性期 D-二聚体、纤维蛋白降解产物（FDP）和纤维蛋白原（Fg）增加。D-二聚体、FDP、Fg 和 APTT 在急性期与 CRP 呈正相关。感染相关急性荨麻疹患者在缓解期 D-二聚体和 FDP 降低。较高的 D-二聚体（>0.48mg/L）和 FDP（>3.84mg/L）可能提示与感染相关的急性荨麻疹。总之，在低静脉血栓栓塞风险的急性荨麻疹中，D-二聚体水平及其动态变化可能可用于感染相关的临床实践管理。
