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聚合物表面涂层合成量子点在治疗和传感应用方面的概述。

An overview of polymer surface coated synthetic quantum dots as therapeutics and sensors applications.

机构信息

Centre of Excellence for Pharmaceutical Sciences, School of Pharmacy, KPJ Healthcare University College, 71800, Nilai, Malaysia.

Parul Institute of Pharmacy & Research, Parul University, Vadodara, Gujarat, 391110, India.

出版信息

Prog Biophys Mol Biol. 2023 Nov;184:1-12. doi: 10.1016/j.pbiomolbio.2023.08.004. Epub 2023 Aug 29.

Abstract

Quantum dots (QDs) are a class of remarkable materials that have garnered significant attention since their initial discovery. It is noteworthy to mention that it took approximately a decade for these materials to be successfully implemented in practical applications. While QDs have demonstrated notable optical properties, it is important to note that these attributes alone have not rendered them a feasible substitute for traditional organic dyes. Furthermore, it is worth noting that the substance under investigation exhibited inherent toxicity and instability in its initial state, primarily due to the presence of a heavy metal core. In the initial stages of research, it was observed that the integration of nanocomposites had a positive impact on the properties of QDs. The discovery of these nanocomposites was motivated by the remarkable properties exhibited by biocomposites found in nature. Recent discoveries have shed light on the potential utilization of QDs as a viable strategy for drug delivery, offering a promising avenue to enhance the efficacy of current pharmaceuticals and pave the way for the creation of innovative therapeutic approaches. The primary objective of this review was to elucidate the distinctive characteristics that render QDs highly suitable for utilization as nanocarriers. In this study, we will delve into the multifaceted applications of QDs as sensing nanoprobes and their utilization in diverse drug delivery systems. The focus of our investigation was directed toward the utilization of QD/polymer composites in sensing applications, with particular emphasis on their potential as chemical sensors, biosensors, and physical sensors.

摘要

量子点 (QDs) 是一类引人注目的材料,自首次发现以来就引起了广泛关注。值得注意的是,这些材料大约花了十年的时间才成功应用于实际应用。虽然 QD 具有显著的光学特性,但重要的是要注意,这些特性本身并没有使它们成为传统有机染料的可行替代品。此外,值得注意的是,研究中所涉及的物质在其初始状态下就表现出内在的毒性和不稳定性,主要是由于存在重金属核心。在研究的早期阶段,人们观察到纳米复合材料的集成对 QD 的性质有积极的影响。这些纳米复合材料的发现是受到自然界中生物复合材料表现出的优异特性的启发。最近的发现揭示了 QD 作为一种可行的药物传递策略的潜力,为提高现有药物的疗效提供了有希望的途径,并为创新治疗方法的创造铺平了道路。本综述的主要目的是阐明使 QD 非常适合用作纳米载体的独特特性。在本研究中,我们将深入探讨 QD 作为传感纳米探针的多方面应用及其在各种药物传递系统中的应用。我们的研究重点是 QD/聚合物复合材料在传感应用中的利用,特别关注它们作为化学传感器、生物传感器和物理传感器的潜力。

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