Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, UK.
Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Allergy. 2024 Feb;79(2):294-301. doi: 10.1111/all.15857. Epub 2023 Aug 31.
While the number and types of indoor air pollutants is rising, much is suspected but little is known about the impact of their potentially synergistic interactions, upon human health. Gases, particulate matter, organic compounds but also allergens and viruses, fall within the 'pollutant' definition. Distinct populations, such as children and allergy and asthma sufferers are highly susceptible, while a low socioeconomic background is a further susceptibility factor; however, no specific guidance is available. We spend most of our time indoors; for children, the school environment is of paramount importance and potentially amenable to intervention. The interactions between some pollutant classes have been studied. However, a lot is missing with respect to understanding interactions between specific pollutants of different classes in terms of concentrations, timing and sequence, to improve targeting and upgrade standards. SynAir-G is a European Commission-funded project aiming to reveal and quantify synergistic interactions between different pollutants affecting health, from mechanisms to real life, focusing on the school setting. It will develop a comprehensive and responsive multipollutant monitoring system, advance environmentally friendly interventions, and disseminate the generated knowledge to relevant stakeholders in accessible and actionable formats. The aim of this article it to put forward the SynAir-G hypothesis, and describe its background and objectives.
尽管室内空气污染物的数量和类型在不断增加，但对于它们潜在协同作用对人类健康的影响，人们了解甚少，尽管有很多怀疑。气体、颗粒物、有机化合物，但也包括过敏原和病毒，都属于“污染物”的定义范围。不同的人群，如儿童、过敏和哮喘患者，非常容易受到影响，而低社会经济背景则是另一个易感性因素；然而，目前没有具体的指导意见。我们大部分时间都在室内度过；对于儿童来说，学校环境至关重要，而且可能适合进行干预。已经研究了一些污染物类别之间的相互作用。然而，在理解不同类别特定污染物之间的相互作用方面，还存在很多空白，包括浓度、时间和顺序，以提高针对性并升级标准。SynAir-G 是一个由欧盟委员会资助的项目，旨在揭示和量化影响健康的不同污染物之间的协同作用，从机制到现实生活，重点关注学校环境。它将开发一个全面和响应式的多污染物监测系统，推进环保干预措施，并以易于理解和可行的格式将生成的知识传播给相关利益相关者。本文旨在提出 SynAir-G 假设，并描述其背景和目标。
