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本文引用的文献

1
Brainstem Evoked Response Audiometry (BERA) in Neonates with Hyperbillirubinemia.高胆红素血症新生儿的脑干听觉诱发电位测定(BERA)
Indian J Otolaryngol Head Neck Surg. 2016 Sep;68(3):334-8. doi: 10.1007/s12070-014-0811-6. Epub 2014 Dec 3.
2
Reversibility of brainstem evoked response audiometry abnormalities at 3 months in term newborns with hyperbilirubinemia.足月新生儿高胆红素血症3个月时脑干听觉诱发电位异常的可逆性
Indian Pediatr. 2014 Feb;51(2):134-5. doi: 10.1007/s13312-014-0346-7. Epub 2013 Sep 5.
3
The economics of screening infants at risk of hearing impairment: an international analysis.对有听力障碍风险的婴儿进行筛查的经济学:一项国际分析。
Int J Pediatr Otorhinolaryngol. 2012 Feb;76(2):212-8. doi: 10.1016/j.ijporl.2011.11.004. Epub 2011 Nov 29.
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Movement of bilirubin and bilirubin conjugates across the placenta.胆红素及胆红素结合物通过胎盘的转运。
Pediatrics. 2007 May;119(5):1032-3; author reply 1033. doi: 10.1542/peds.2006-3669.
5
Brainstem auditory evoked response in neonatal neurology.新生儿神经病学中的脑干听觉诱发电位
Semin Fetal Neonatal Med. 2006 Dec;11(6):444-51. doi: 10.1016/j.siny.2006.07.005. Epub 2006 Oct 2.
6
Brainstem evoked response audiometry (BAER) in neonates with hyperbilirubinemia.高胆红素血症新生儿的脑干听觉诱发电位测定(BAER)
Indian J Pediatr. 2006 May;73(5):413-6. doi: 10.1007/BF02758564.
7
Sensorineural hearing loss in children.儿童感音神经性听力损失
Lancet. 2005;365(9462):879-90. doi: 10.1016/S0140-6736(05)71047-3.
8
Bilirubin toxicity in the developing nervous system.发育中神经系统的胆红素毒性。
Pediatr Neurol. 2003 Nov;29(5):410-21. doi: 10.1016/j.pediatrneurol.2003.09.011.
9
Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants.极低出生体重儿血清胆红素峰值与神经发育结局的关联
Pediatrics. 2003 Oct;112(4):773-9. doi: 10.1542/peds.112.4.773.
10
Identification of neonatal hearing impairment: characteristics of infants in the neonatal intensive care unit and well-baby nursery.新生儿听力障碍的识别:新生儿重症监护病房和健康婴儿护理室中婴儿的特征
Ear Hear. 2000 Oct;21(5):373-82. doi: 10.1097/00003446-200010000-00005.

高胆红素血症新生儿恢复后脑干听觉诱发电位反应的评估:一项原创研究

Evaluation of the Brain Stem Auditory Evoked Potential Response among New Borns Post-Recovery after Hyper-Bilirubinemia: An Original Research.

作者信息

Dolma Kunzes, Thekkethil Jathin Sam, Paul Anish G, Rao P Srinivas Narasinga, Parikh Taral, Somaraj Vinej

机构信息

Department of ENT, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Specialist ENT, Burjeel Medical Centre, Abu Dhabi, United Arab Emirates.

出版信息

J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S268-S272. doi: 10.4103/jpbs.jpbs_476_22. Epub 2023 Jul 5.

DOI:10.4103/jpbs.jpbs_476_22
PMID:37654294
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10466513/
Abstract

INTRODUCTION

Neurological harm from neonatal hyperbilirubinemia includes loss of hearing and encephalopathy. The current research used the " test to screen for as well as assess hearing loss in newborns who had recovered from hyperbilirubinemia.

MATERIALS AND PROCEDURES

A cross-sectional comparative investigation was conducted at a tertiary care center. Fifty neonates were included out of which 25 were healthy and 25 received treatment for the increased bilirubin. Prior to BERA testing, the subjects' ears were examined for any obstruction. Following a conventional lab procedure described, the BERA recordings were carried out after the neonate fell asleep on its own. The data collected were compared for the significance using the , keeping < 0.05 as significant.

RESULTS

In comparison to the controls, a large proportion of neonates in cases had BERA wave latencies that were delayed (I-R = 80, L = 84; III- R = 76, L = 84; V- R = 84, L = 88 percentages latencies). The percentage of subjects in whom the latencies was noted for the healthy neonates was lesser than the case group (I-R = 8, L = 24; III- R = 8, L = 8; V- R = 4, L = 12 percentages latencies). Comparable numbers of infants in each group had inter-peak latencies that were lengthy. Subjects in the case group showed that the threshold hearing as per the WHO grade was mild (R = 32, L = 36) and moderate (R = 32, L = 28).

CONCLUSION

Elevated serum bilirubin may cause damage to hearing capability. After hyperbilirubinemia has been completely treated, BERA can detect even the slightest degree of hearing damage. BERA is therefore a useful technique for the quick recognition of hearing impairment in newborns. Early treatment helps in the prognosis so that the neurosensory systems can fully mature, and the patient can lead a quality life.

摘要

引言

新生儿高胆红素血症所致的神经损伤包括听力丧失和脑病。当前研究采用该“测试”对从高胆红素血症中康复的新生儿进行听力损失筛查及评估。

材料与方法

在一家三级护理中心开展了一项横断面比较研究。纳入了50名新生儿,其中25名健康,25名因胆红素升高接受治疗。在进行脑干听觉诱发电位(BERA)测试前,检查受试者耳朵有无堵塞。按照所述的常规实验室程序,待新生儿自行入睡后进行BERA记录。使用 对收集到的数据进行显著性比较,将 < 0.05视为具有显著性。

结果

与对照组相比,病例组中很大一部分新生儿的BERA波潜伏期延迟(I-R = 80,L = 84;III-R = 76,L = 84;V-R = 84,L = 88 潜伏期百分比)。健康新生儿中记录到潜伏期的受试者百分比低于病例组(I-R = 8,L = 24;III-R = 8,L = 8;V-R = 4,L = 12 潜伏期百分比)。每组中相当数量的婴儿峰间潜伏期较长。病例组中的受试者显示,根据世界卫生组织分级,阈值听力为轻度(R = 32,L = 36)和中度(R = 32,L = 28)。

结论

血清胆红素升高可能会损害听力。高胆红素血症完全治愈后,BERA甚至可以检测到最轻微的听力损伤。因此,BERA是快速识别新生儿听力障碍的有用技术。早期治疗有助于改善预后,使神经感觉系统能够充分成熟,患者能够过上有质量的生活。