Dolma Kunzes, Thekkethil Jathin Sam, Paul Anish G, Rao P Srinivas Narasinga, Parikh Taral, Somaraj Vinej
Department of ENT, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Specialist ENT, Burjeel Medical Centre, Abu Dhabi, United Arab Emirates.
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S268-S272. doi: 10.4103/jpbs.jpbs_476_22. Epub 2023 Jul 5.
Neurological harm from neonatal hyperbilirubinemia includes loss of hearing and encephalopathy. The current research used the " test to screen for as well as assess hearing loss in newborns who had recovered from hyperbilirubinemia.
A cross-sectional comparative investigation was conducted at a tertiary care center. Fifty neonates were included out of which 25 were healthy and 25 received treatment for the increased bilirubin. Prior to BERA testing, the subjects' ears were examined for any obstruction. Following a conventional lab procedure described, the BERA recordings were carried out after the neonate fell asleep on its own. The data collected were compared for the significance using the , keeping < 0.05 as significant.
In comparison to the controls, a large proportion of neonates in cases had BERA wave latencies that were delayed (I-R = 80, L = 84; III- R = 76, L = 84; V- R = 84, L = 88 percentages latencies). The percentage of subjects in whom the latencies was noted for the healthy neonates was lesser than the case group (I-R = 8, L = 24; III- R = 8, L = 8; V- R = 4, L = 12 percentages latencies). Comparable numbers of infants in each group had inter-peak latencies that were lengthy. Subjects in the case group showed that the threshold hearing as per the WHO grade was mild (R = 32, L = 36) and moderate (R = 32, L = 28).
Elevated serum bilirubin may cause damage to hearing capability. After hyperbilirubinemia has been completely treated, BERA can detect even the slightest degree of hearing damage. BERA is therefore a useful technique for the quick recognition of hearing impairment in newborns. Early treatment helps in the prognosis so that the neurosensory systems can fully mature, and the patient can lead a quality life.
新生儿高胆红素血症所致的神经损伤包括听力丧失和脑病。当前研究采用该“测试”对从高胆红素血症中康复的新生儿进行听力损失筛查及评估。
在一家三级护理中心开展了一项横断面比较研究。纳入了50名新生儿,其中25名健康,25名因胆红素升高接受治疗。在进行脑干听觉诱发电位(BERA)测试前,检查受试者耳朵有无堵塞。按照所述的常规实验室程序,待新生儿自行入睡后进行BERA记录。使用 对收集到的数据进行显著性比较,将 < 0.05视为具有显著性。
与对照组相比,病例组中很大一部分新生儿的BERA波潜伏期延迟(I-R = 80,L = 84;III-R = 76,L = 84;V-R = 84,L = 88 潜伏期百分比)。健康新生儿中记录到潜伏期的受试者百分比低于病例组(I-R = 8,L = 24;III-R = 8,L = 8;V-R = 4,L = 12 潜伏期百分比)。每组中相当数量的婴儿峰间潜伏期较长。病例组中的受试者显示,根据世界卫生组织分级,阈值听力为轻度(R = 32,L = 36)和中度(R = 32,L = 28)。
血清胆红素升高可能会损害听力。高胆红素血症完全治愈后,BERA甚至可以检测到最轻微的听力损伤。因此,BERA是快速识别新生儿听力障碍的有用技术。早期治疗有助于改善预后,使神经感觉系统能够充分成熟,患者能够过上有质量的生活。