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可能的原发性皮肤CD8 +侵袭性亲表皮细胞毒性T细胞淋巴瘤：一例诊断难题的病例报告

Probable Primary Cutaneous CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma: A Case Report of a Diagnostic Challenge.

作者信息

Velarde Loya Marcela, Millan Reza Monica G, Olaya Cordova Mariana, Chavéz López Zaira D

机构信息

Internal Medicine Residency, Hospital General Presidente Lázaro Cárdenas, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Chihuahua, MEX.

Dermatology, Universidad Nacional Autónoma de México (UNAM), Chihuahua, MEX.

出版信息

Cureus. 2023 Aug 30;15(8):e44375. doi: 10.7759/cureus.44375. eCollection 2023 Aug.

DOI:10.7759/cureus.44375
PMID:37654908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10467331/
Abstract

Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma is a rare variety of cutaneous lymphoma. This subtype has an aggressive and quickly progressive clinical course with a survival time of 32 months from the commencement of skin lesions. This article describes a probable case of primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma in a 63-year-old female, which manifested as diffuse non-pruritic erythematous plaques and nodules. The diagnosis of this possible entity was aided by the histopathological and immunohistochemical findings, while immunohistochemistry for T-cell receptor (TCR) gamma/delta could not be done.

摘要

原发性皮肤CD8+侵袭性亲表皮细胞毒性T细胞淋巴瘤是一种罕见的皮肤淋巴瘤亚型。该亚型具有侵袭性且进展迅速的临床病程，从皮肤病变开始算起生存期为32个月。本文描述了一例63岁女性可能患有原发性皮肤CD8+侵袭性亲表皮细胞毒性T细胞淋巴瘤的病例，其表现为弥漫性非瘙痒性红斑斑块和结节。组织病理学和免疫组化结果有助于诊断这一可能的疾病实体，而T细胞受体（TCR）γ/δ的免疫组化未能进行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/f7910f9419f7/cureus-0015-00000044375-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/4d37533fac87/cureus-0015-00000044375-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/8ce1f5db24d6/cureus-0015-00000044375-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/f7910f9419f7/cureus-0015-00000044375-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/4d37533fac87/cureus-0015-00000044375-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/8ce1f5db24d6/cureus-0015-00000044375-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/30f7/10467331/f7910f9419f7/cureus-0015-00000044375-i03.jpg

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