原发性皮肤 CD8+侵袭性亲表皮细胞毒性 T 细胞淋巴瘤早期诊断的挑战：四例患者的病例系列研究。
Challenges in early diagnosis of primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma: a case series of four patients.
机构信息
Department of Dermatology, Bezmialem Vakif University Faculty of Medicine.
Department of Pathology, Bezmialem Vakif University Faculty of Medicine.
出版信息
Eur J Dermatol. 2020 Aug 1;30(4):358-361. doi: 10.1684/ejd.2020.3843.
BACKGROUND
Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma (AECTCL) is a rare and aggressive lymphoma characterised by ulcerated lesions and a poor prognosis.
OBJECTIVES
To present a case series of four previously misdiagnosed AECTCL patients and discuss the importance of early diagnosis.
MATERIALS AND METHODS
All patients in this study were identified from the database of the Dermatology Department of the Medical School of Bezmialem Vakif University, based on clinical and histopathological diagnosis of AECTCL between 2010 and 2018.
RESULTS
AECTCL cases may mimic many benign dermatoses and accurate diagnosis may be delayed.
CONCLUSION
Because of its poor prognosis, early diagnosis of AECTCL may be helpful in improving the likelihood of patient survival, but further study is needed to address the challenges in diagnosing this rare and aggressive lymphoma.
背景
原发性皮肤侵袭性表皮 CD8+细胞毒性 T 细胞淋巴瘤（AECTCL）是一种罕见且侵袭性强的淋巴瘤，其特征为溃疡性病变和预后不良。
目的
报告 4 例先前误诊的 AECTCL 患者，并讨论早期诊断的重要性。
材料和方法
本研究中的所有患者均根据 2010 年至 2018 年贝西梅亚勒姆瓦基夫大学医学院皮肤科的 AECTCL 的临床和组织病理学诊断，从数据库中确定。
结果
AECTCL 病例可能模仿许多良性皮肤病，因此可能会延迟准确诊断。
结论
由于预后不良，早期诊断 AECTCL 可能有助于提高患者生存的可能性，但需要进一步研究来解决诊断这种罕见且侵袭性淋巴瘤的挑战。
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