[三种维甲酸对实验性肿瘤生长的影响]
[Effect of three retinoids on the growth of experimental tumors].
作者信息
Nozdrin V I, Samokhvalov G I, Zhidkova T A, Poliachenko L N, Vakulova L A
出版信息
Vopr Med Khim. 1986 Jul-Aug;32(4):133-6.
PMID:3765491
Abstract
Influence of retinoid C17-diester retinyldimedone and L-tocopherylretinoate on the growth of transplanted tumors was investigated in F1 (C57Bl/6 X CBA) strain of mice. The retinoids studied proved to be less toxic than retinoic acid. Both retinoid C17-diester and L-tocopherylretinoate reduced growth of cervical cancer, while retinyldimedone inhibited growth of Lewis carcinoma (lung tumor) and of stomach carcinoma.
摘要
在F1（C57Bl/6×CBA）品系小鼠中研究了类视黄醇C17 - 二酯视黄基二甲基酮和L - 生育酚视黄酸酯对移植肿瘤生长的影响。所研究的类视黄醇被证明比视黄酸毒性更小。类视黄醇C17 - 二酯和L - 生育酚视黄酸酯都能减缓子宫颈癌的生长，而视黄基二甲基酮则抑制刘易斯肺癌和胃癌的生长。
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