Hackl W, Frohner K, Podczek A, Unger G, Steinbach K
Wien Klin Wochenschr. 1986 Sep 12;98(17):581-4.
The effect of 4 mg Molsidomine iv. followed by a continuous infusion of 3 mg per hour for 3 hours on arterial blood pressure, pulmonary artery pressure, cardiac index, peripheral and pulmonary vascular resistance and heart rate was evaluated in eleven patients suffering from chronic heart failure caused by non-ischaemic dilatative cardiomyopathy (NYHA II-III). A significant decrease in systemic blood pressure, systolic and mean pulmonary artery pressure and pulmonary wedge pressure was observed and also a marked decrease in total peripheral and pulmonary vascular resistance. There was a slight, but not significant increase in cardiac index. The heart rate did not change significantly. Treatment had to be stopped in one patient because of side effects (hypotension, nausea).
对11例由非缺血性扩张型心肌病导致慢性心力衰竭（纽约心脏协会心功能分级II - III级）的患者，评估静脉注射4毫克吗多明，随后以每小时3毫克的速度持续输注3小时，对动脉血压、肺动脉压、心脏指数、外周及肺血管阻力和心率的影响。观察到全身血压、收缩压和平均肺动脉压以及肺楔压显著下降，外周和肺总血管阻力也明显降低。心脏指数有轻微但不显著的升高。心率无显著变化。1例患者因副作用（低血压、恶心）而不得不停止治疗。
