Zeitlhofer J, Maida E M, Mamoli B, Mayr N
Wien Med Wochenschr. 1986 Jul 15;136(13):329-32.
In a retrospective study in 47 patients with myasthenia gravis acetylcholine-receptor-antibody-titers (AChR-AB) were correlated with the severity of the disease. In 18 patients the course of titers was studied and two groups of patients could be differentiated: patients with relative constant and patients with fluctuating titers. Age, age of begin of myasthenia and sex did not influence the titers. Also the duration of the disease and the severity of symptoms did not influence the level of AChR-AB-titers. In this retrospective study the influence of immun-suppressive therapy on the intra-individual course of AB-titers and their correlation with the clinical symptoms could not be judged. Measurement of AChR-AB is of value for the diagnosis of myasthenia gravis and important for judging the clinical course and the effect of therapy.
在一项对47例重症肌无力患者的回顾性研究中，乙酰胆碱受体抗体滴度（AChR-AB）与疾病严重程度相关。对18例患者的抗体滴度变化过程进行了研究，可将患者分为两组：抗体滴度相对稳定的患者和抗体滴度波动的患者。年龄、重症肌无力起病年龄和性别均不影响抗体滴度。疾病持续时间和症状严重程度也不影响AChR-AB滴度水平。在这项回顾性研究中，无法判断免疫抑制治疗对个体抗体滴度变化过程的影响及其与临床症状的相关性。检测AChR-AB对重症肌无力的诊断有价值，对判断临床病程和治疗效果也很重要。
