Smolka Petr, Kadlečková Markéta, Kocourková Karolína, Bartoňová Martina, Mikulka Filip, Knechtová Eliška, Mráček Aleš, Musilová Lenka, Humenik Martin, Minařík Antonín
Department of Physics and Materials Engineering, Tomas Bata University in Zlín, Vavrečkova 5669, Zlín 760 01, Czech Republic.
Centre of Polymer Systems, Tomas Bata University in Zlín, Třída Tomáše Bati 5678, Zlín 760 01, Czech Republic.
Langmuir. 2023 Sep 19;39(37):13140-13148. doi: 10.1021/acs.langmuir.3c01547. Epub 2023 Sep 1.
This work explores application of phase separation phenomena for structuring of films made from hyaluronan. A time-sequenced dispensing of different solution mixtures was applied under rotation of hyaluronan-covered substrates to generate surface textures. This method is applicable in direct surface modification or cover layer deposition. Changes in the surface topography were characterized by atomic force microscopy, optical microscopy, and contact and non-contact profilometry. The mechanical properties of the surface-modified self-supporting films were compared using a universal testing machine. Experimental results show that diverse hyaluronan-based surface reliefs and self-supporting films with improved mechanical properties can be prepared using a newly designed multi-step phase separation process without the need for sacrificial removable templates or additives.
这项工作探索了相分离现象在由透明质酸制成的薄膜结构化中的应用。在覆盖有透明质酸的基材旋转的情况下,对不同溶液混合物进行时间序列分配,以产生表面纹理。该方法适用于直接表面改性或覆盖层沉积。通过原子力显微镜、光学显微镜以及接触式和非接触式轮廓仪对表面形貌的变化进行了表征。使用万能试验机比较了表面改性自支撑薄膜的力学性能。实验结果表明,使用新设计的多步相分离工艺,可以制备出具有不同基于透明质酸的表面浮雕和力学性能得到改善的自支撑薄膜,而无需牺牲性可移除模板或添加剂。