肌肉特性、粗大运动功能和生活质量在镰状细胞病患儿中的表现。
Muscle Properties, Gross Motor Performance, and Quality of Life in Children With Sickle Cell Disease.
机构信息
Departments of Physical Therapy and Rehabilitation Science (Drs Rock, Ho, Gray, Addison, and Marchese) and Pediatrics (Dr York), University of Maryland School of Medicine, Baltimore, Maryland; Department of Hematology/Oncology, University of Maryland Medical Center, Baltimore, Maryland (Dr York and Mss Keegan Wells and DeLuca).
出版信息
Pediatr Phys Ther. 2023 Oct 1;35(4):450-456. doi: 10.1097/PEP.0000000000001037. Epub 2023 Sep 2.
PURPOSE
To explore muscle properties, gross motor performance, and quality of life (QoL) in children with sickle cell disease (SCD) compared with controls and to assess relationships among these outcomes.
METHODS
A cross-sectional study of 24 children assessed muscle properties including: knee extension strength by dynamometry; vastus lateralis (VL) and rectus femoris (RF) muscle thickness by ultrasonography; and VL and RF neuromuscular activation (rate of muscle activation [RoA]) by electromyography (EMG). Gross motor performance and QoL were assessed by standardized tests and questionnaires.
RESULTS
Children with SCD had impaired knee extension strength, VL EMG RoA, gross motor performance, and QoL compared with children without SCD. Relationships among muscle properties, gross motor performance, and QoL were identified.
CONCLUSIONS
These findings indicate that comprehensive muscle properties, gross motor performance, and QoL assessments should be considered to support and develop individualized physical therapy plans for children with SCD.
目的
与对照组相比，探索镰状细胞病（SCD）患儿的肌肉特性、粗大运动表现和生活质量（QoL），并评估这些结果之间的关系。
方法
对 24 名儿童进行了一项横断面研究，评估了肌肉特性，包括：通过测力法评估膝关节伸展力量；通过超声评估股外侧肌（VL）和股直肌（RF）的肌肉厚度；通过肌电图（EMG）评估 VL 和 RF 神经肌肉激活（肌肉激活率[RoA]）。通过标准化测试和问卷评估粗大运动表现和生活质量。
结果
与无 SCD 的儿童相比，SCD 患儿的膝关节伸展力量、VL EMG RoA、粗大运动表现和生活质量受损。确定了肌肉特性、粗大运动表现和生活质量之间的关系。
结论
这些发现表明，应考虑对 SCD 患儿进行全面的肌肉特性、粗大运动表现和生活质量评估，以支持和制定个性化的物理治疗计划。
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