Department of rehabilitation medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.
Department of Rehabilitation, Zhejiang Tongde Hospital, Hangzhou, Zhejiang, China.
Medicine (Baltimore). 2023 Sep 1;102(35):e34764. doi: 10.1097/MD.0000000000034764.
Accumulating evidence has indicated a possible connection between post-stroke cognitive impairment (PSCI) and gut microbiota imbalance. To further investigate this association, the present work was designed to systematically assess the dissimilarity of gut microbiota between PSCI and healthy individuals or stroke patients.
A meta-analysis and systematic review was conducted by searching various databases including PubMed, Web of Science, Embase, VIP, CNKI, and Wangfang for relevant studies. The pooled outcomes were used to estimate the combined dissimilarity of gut microbiota composition between PSCI and healthy individuals or patients with stroke.
Nine eligible studies were included in this meta-analysis. The results showed that there were no significant changes in observed richness indexes (Chao1 and ACE) and Shannon index. Notably, a significant decrease in Simpson index was observed in PSCI patients in comparison to the healthy individuals (-0.31, 95% CI: -0.62 to -0.01, P = 0.04). Moreover, the microbiota composition at the phylum level (increased abundance of Proteobacteria), family level (increased abundance of Bacteroidaceae, Lachnospiraceae, and Veillonellaceae; decreased abundance of Enterobacteriaceae), and genus level (increased abundance of Bacteroides, Clostridium XIVa, and Parabacteroides; decreased abundance of Prevotella and Ruminococcus) was found to be significantly different between PSCI and controls.
This meta-analysis suggests a significant shift of observed species and microbiota composition in PSCI compared to healthy individuals or patients with stroke.
越来越多的证据表明，卒中后认知障碍（PSCI）与肠道微生物失衡之间可能存在关联。为了进一步研究这种关联，本研究旨在系统评估 PSCI 与健康个体或卒中患者之间肠道微生物群落的差异。
通过检索 PubMed、Web of Science、Embase、VIP、CNKI 和万方等数据库，进行荟萃分析和系统评价，以搜索相关研究。汇总结果用于估计 PSCI 与健康个体或卒中患者之间肠道微生物群落组成的综合差异。
本荟萃分析纳入了 9 项符合条件的研究。结果显示，观察到的丰富度指数（Chao1 和 ACE）和 Shannon 指数没有显著变化。值得注意的是，与健康个体相比，PSCI 患者的 Simpson 指数显著降低（-0.31，95%CI：-0.62 至 -0.01，P=0.04）。此外，在门水平（厚壁菌门丰度增加）、科水平（拟杆菌科、lachnospiraceae 和 veillonellaceae 丰度增加，肠杆菌科丰度降低）和属水平（拟杆菌属、梭菌属 XIVa 和 parabacteroides 丰度增加，普雷沃氏菌属和瘤胃球菌属丰度降低），PSCI 患者的微生物群落组成也存在显著差异。
与健康个体或卒中患者相比，PSCI 患者的观察物种和微生物群落组成存在显著变化。
