Carrión Ricardo E, Auther Andrea M, McLaughlin Danielle, Adelsheim Steven, Burton Cynthia Z, Carter Cameron S, Niendam Tara, Ragland J Daniel, Sale Tamara G, Taylor Stephan F, Tso Ivy F, McFarlane William R, Cornblatt Barbara A
Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 75-59 263rd Street, Glen Oaks, NY 11004, United States; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York 11549, United States.
Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, 75-59 263rd Street, Glen Oaks, NY 11004, United States; Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York 11549, United States.
Psychiatry Res. 2023 Oct;328:115420. doi: 10.1016/j.psychres.2023.115420. Epub 2023 Aug 15.
Recreational cannabis use has recently gained considerable interest as an environmental risk factor that triggers the onset of psychosis. To date, however, the evidence that cannabis is associated with negative outcomes in individuals at clinical high risk (CHR) for psychosis is inconsistent. The present study tracked cannabis usage over a 2-year period and examined its associations with clinical and neurocognitive outcomes, along with medication rates. CHR youth who continuously used cannabis had higher neurocognition and social functioning over time, and decreased medication usage, relative to non-users. Surprisingly, clinical symptoms improved over time despite the medication decreases.
作为引发精神病发作的一个环境风险因素，消遣性使用大麻最近引起了相当大的关注。然而，迄今为止，大麻与临床高危（CHR）精神病个体的负面结果相关的证据并不一致。本研究追踪了两年期间的大麻使用情况，并检查了其与临床和神经认知结果以及用药率的关联。与不使用者相比，持续使用大麻的CHR青年随着时间推移具有更高的神经认知和社会功能，且用药量减少。令人惊讶的是，尽管用药量减少，但临床症状随着时间推移有所改善。
