利用加权单步全基因组关联研究对黄羽肉鸡生长性状潜在遗传因素的调查。
Investigation of potential genetic factors for growth traits in yellow-feather broilers using weighted single-step genome-wide association study.
作者信息
Fang Xiang, Ye Haoqiang, Zhang Siyu, Guo Lijin, Xu Yibin, Zhang Dexiang, Nie Qinghua
机构信息
State Key Laboratory of Livestock and Poultry Breeding, & Lingnan Guangdong Laboratory of Agriculture, South China Agricultural University, & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affair, South China Agricultural University, Guangzhou 510642, China.
State Key Laboratory of Livestock and Poultry Breeding, & Lingnan Guangdong Laboratory of Agriculture, South China Agricultural University, & Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affair, South China Agricultural University, Guangzhou 510642, China; Henry Fok School of Biology and Agriculture, Shaoguan University, Shaoguan 512005, China.
出版信息
Poult Sci. 2023 Nov;102(11):103034. doi: 10.1016/j.psj.2023.103034. Epub 2023 Aug 18.
Yellow-feather broilers take a large portion of poultry industry in China due to its meat characteristics. Improving the growth traits of yellow-feathered broilers will have great significance for the Chinese poultry market. The current study was designed to investigate the potential genetic factors using the weighted single-step genome-wide association study (wssGWAS) method, which takes consideration of more factors including pedigree, sex, environment and has more accuracy than traditional GWAS. The yellow-feather dwarf chickens from Wens Nanfang Poultry Breeding Co. Ltd. were revolved to recode 9 growth traits: Average daily gain (ADG), body weight (BW) at 45 d, 49 d, 56 d, 63 d, 70 d, 77 d, 84 d, 91 d for analysis. For the results, the region 4.63 to 5.03 Mb on chromosome 15, which was the QTL overlapped in BW45, BW49, BW56, BW63, BW84, might be the crucial genetic region for growth traits. Seven GO terms and 3 KEGG pathways, GO:0005200, GO:0005882, GO:0045111, GO:0099513, GO:0099081, GO:0099512, GO:0099080, KEGG:gga04020, KEGG:gga04540, KEGG:gga04210, were detected to relevant with growth traits. The genes enriched in these biological processes (NRAS, TUBB1, ADORA2B, NTRK3, NGF, TNNC2, F-KER, LOC429492, LOC431325, LOC431324, LOC396480) might have the function in growth of yellow-feather broilers.
由于其肉质特性，黄羽肉鸡在中国家禽产业中占据很大比例。改善黄羽肉鸡的生长性状对中国家禽市场具有重要意义。本研究旨在采用加权单步全基因组关联研究（wssGWAS）方法调查潜在的遗传因素，该方法考虑了包括系谱、性别、环境等更多因素，比传统的GWAS更准确。对温氏南方家禽育种有限公司的黄羽矮小鸡进行测定，记录9个生长性状：平均日增重（ADG）、45日龄、49日龄、56日龄、63日龄、70日龄、77日龄、84日龄、91日龄的体重（BW）进行分析。结果显示，15号染色体上4.63至5.03 Mb区域，该区域在BW45、BW49、BW56、BW63、BW84中是重叠的QTL，可能是生长性状的关键遗传区域。检测到7个GO术语和3条KEGG通路，即GO:0005200、GO:0005882、GO:0045111、GO:0099513、GO:0099081、GO:0099512、GO:0099080、KEGG:gga04020、KEGG:gga04540、KEGG:gga04210，与生长性状相关。富集在这些生物学过程中的基因（NRAS、TUBB1、ADORA2B、NTRK3、NGF、TNNC2、F-KER、LOC429492、LOC431325、LOC431324、LOC396480）可能对黄羽肉鸡的生长具有作用。
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