期待对多发性硬化症女性性功能障碍的管理及与临床特征的关联。

Expectations about the management of sexual dysfunction in women with multiple sclerosis and association with clinical characteristics.

机构信息

GRC 01, Service de Neuro-Urologie, Green Group of Clinical Research in Neuro-Urology AP-HP, Sorbonne Université, AP-HP, Hôpital Tenon, 4, rue de la Chine, Paris F-75020, France.

出版信息

Mult Scler Relat Disord. 2023 Nov;79:104950. doi: 10.1016/j.msard.2023.104950. Epub 2023 Aug 21.

DOI:10.1016/j.msard.2023.104950

PMID:37657309

Abstract

BACKGROUND

Sexual dysfunction (SD) is common in women with multiple sclerosis (MS) and affects their quality of life.

OBJECTIVES

The primary aim is to assess their expectations concerning SD management. The secondary aim is to identify if expectations were associated with specific patient's characteristics.

METHODS

All women with MS who underwent a urodynamic assessment in a neuro-urology clinic and had a standardized assessment of SD expectations between June 2020 and November 2022 were retrospectively screened. Demographic data and assessment of bladder, bowel, and sexual dysfunctions with validated questionnaires were collected.

RESULTS

One hundred and sixty-seven patients were included in the study (mean age 47.9 ± 12.5 years). Expectations on SD information or management were reported by 112 (67.1%) patients. Interest in SD information and management was less frequent after menopause (56% vs 80%, p = 0.004), and in those with EDSS>6 (49% vs 74%, p = 0.03) and progressive type of MS (54% vs 71% p = 0.003). In multivariate analysis, the progressive type of MS was the only criterion related to a lack of interest (OR=2.9 IC95% [1.09; 7.72]).

CONCLUSIONS

Women with MS have high expectations on treatment and information about SD. A systematic screening of SD expectations should be encouraged.

摘要

背景

性功能障碍（SD）在多发性硬化症（MS）女性中很常见，影响她们的生活质量。

目的

主要目的是评估她们对 SD 管理的期望。次要目的是确定这些期望是否与特定患者的特征有关。

方法

回顾性筛选了 2020 年 6 月至 2022 年 11 月期间在神经泌尿科诊所接受尿动力学评估且对 SD 期望进行了标准化评估的所有 MS 女性患者。收集了人口统计学数据和使用验证问卷评估膀胱、肠道和性功能障碍。

结果

本研究共纳入 167 例患者（平均年龄 47.9 ± 12.5 岁）。112 例（67.1%）患者报告了对 SD 信息或管理的期望。绝经后（56% 对 80%，p = 0.004）和 EDSS>6（49% 对 74%，p = 0.03）以及进展型 MS（54% 对 71%，p = 0.003）的患者对 SD 信息和管理的兴趣较低。多变量分析显示，进展型 MS 是缺乏兴趣的唯一相关标准（OR=2.9 95%CI [1.09; 7.72]）。