Róna G
Z Gesamte Inn Med. 1986 Jun 15;41(12):355-8.
It is reported on 6 patients with Wolff-Parkinson-White syndrome in whom spontaneously appeared auricular fibrillation with high ventricular frequency. By the intravenous administration of mexiletine in three patients the sinus rhythm could be restored. In two patients at first only a reduction of the tachycardia and a disappearing of the QRS-broadening took place; the additional administration of quinidine then led to the return of the sinus rhythm. In one patient, despite combined treatment, the return of sinus rhythm could not be achieved, mexiletine, however, led at once to the decrease of the ventricular rate, to the normalisation of the QRS-duration and to the disappearance of all signs of congestive heart failure. The therapeutic mechanism of mexiletine in the Wolff-Parkinson-White syndrome is discussed and it administration for the treatment of the cases complicated by auricular fibrillation is recommended.
据报道，6例预激综合征患者自发出现心房颤动且心室率快。3例患者静脉注射美西律后可恢复窦性心律。2例患者起初仅心动过速减轻且QRS波增宽消失；随后加用奎尼丁使窦性心律恢复。1例患者尽管联合治疗仍未恢复窦性心律，但美西律立即使心室率减慢、QRS时限正常化且所有充血性心力衰竭体征消失。文中讨论了美西律在预激综合征中的治疗机制，并推荐其用于治疗并发心房颤动的病例。
