Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, PR China; Department of Psychiatry and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Department of Outpatient, West China Hospital of Sichuan University, Chengdu 610041, PR China.
J Affect Disord. 2023 Nov 15;341:236-247. doi: 10.1016/j.jad.2023.08.129. Epub 2023 Aug 30.
Although the association between gut microbiota and the pathogenesis of major depressive disorder (MDD) has been well studied, it is unclear whether gut microbiota affects cognitive function in patients with MDD. In this study, we explored the association between gut microbiota and cognitive function in MDD and its possible mechanisms.
We enrolled 57 patients with MDD and 30 healthy controls (HCs) and used 16S rRNA gene sequencing analysis and shotgun metagenomic sequencing analysis to determine gut microbial composition.
The richness and diversity of gut microbiota in patients with MDD were the same as those in HCs, but there were differences in the abundance of Bifidobacterium and Blautia. Compared with HCs, two strains (bin_32 and bin_55) were significantly increased, and one strain (bin_31) was significantly decreased in patients with MDD based on the strain-level meta-analysis. Time to complete the Stroop-C had significant negative correlations with bin_31 and bin_32. Bin_55 had significant negative correlations with time to complete the Stroop-C, time to complete the Stroop-CW, and repeated animal words in 60 s but significant positive correlations with correct answers in 120 s on the Stroop-CW.
This study only tested the cognitive function of MDD in a small sample, which may have caused some bias.
Based on our strain-level analysis, we found that gut microbiota may be associated with the pathogenesis of MDD and may have potential effects on cognitive function.
尽管肠道微生物群与重度抑郁症（MDD）发病机制之间的关联已得到充分研究，但尚不清楚肠道微生物群是否会影响 MDD 患者的认知功能。在这项研究中，我们探讨了 MDD 患者肠道微生物群与认知功能之间的关联及其可能的机制。
我们招募了 57 名 MDD 患者和 30 名健康对照者（HCs），并使用 16S rRNA 基因测序分析和鸟枪法宏基因组测序分析来确定肠道微生物组成。
MDD 患者肠道微生物群的丰富度和多样性与 HCs 相同，但双歧杆菌和布劳特氏菌的丰度存在差异。与 HCs 相比，基于菌株水平荟萃分析，MDD 患者中有两个菌株（bin_32 和 bin_55）显著增加，一个菌株（bin_31）显著减少。完成 Stroop-C 的时间与 bin_31 和 bin_32 呈显著负相关。Bin_55 与完成 Stroop-C 的时间、完成 Stroop-CW 的时间以及 60 秒内重复动物单词呈显著负相关，但与 Stroop-CW 上 120 秒内的正确答案呈显著正相关。
本研究仅在小样本中测试了 MDD 的认知功能，这可能导致了一些偏差。
基于我们的菌株水平分析，我们发现肠道微生物群可能与 MDD 的发病机制有关，并可能对认知功能有潜在影响。
