Luqman Ameer, He Mei, Hassan Adil, Ullah Mehtab, Zhang Liyuan, Rashid Khan Muhammad, Din Ahmad Ud, Ullah Kamran, Wang Wei, Wang Guixue
Key Laboratory for Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implant, Bioengineering College of Chongqing University, Chongqing, China.
Chongqing University Cancer Hospital, Chongqing, China.
Front Psychiatry. 2024 Feb 9;15:1295766. doi: 10.3389/fpsyt.2024.1295766. eCollection 2024.
Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the "second brain," has an important role in the CNS by regulating it through chemical, immunological, hormonal, and neurological processes. Various studies have found a significant bidirectional link between the brain and the gut, emphasizing the onset of depression therapies. The biological and molecular processes underlying depression and microbiota are required, as the bidirectional association may represent a novel study. However, profound insights into the stratification and diversity of the gut microbiota are still uncommon. This article investigates the emerging evidence of a bacterial relationship between the gut and the brain's neurological system and its potential pathogenicity and relevance. The interplay of microbiota, immune system, nervous system neurotransmitter synthesis, and neuroplasticity transitions is also widely studied. The consequences of stress, dietary fibers, probiotics, prebiotics, and antibiotics on the GB axis are being studied. Multiple studies revealed the processes underlying this axis and led to the development of effective microbiota-based drugs for both prevention and treatment. Therefore, the results support the hypothesis that gut microbiota influences depression and provide a promising area of research for an improved knowledge of the etiology of the disease and future therapies.
抑郁症被认为是一种多方面且复杂的精神障碍，因其对全球健康问题有重大影响而日益受到关注。人体肠道微生物群，也被称为“第二大脑”，通过化学、免疫、激素和神经过程对中枢神经系统进行调节，在其中发挥着重要作用。多项研究发现大脑与肠道之间存在显著的双向联系，这凸显了抑郁症治疗的开端。由于这种双向关联可能代表一项新研究，所以需要了解抑郁症和微生物群背后的生物学和分子过程。然而，对肠道微生物群的分层和多样性进行深入洞察的情况仍然并不常见。本文探讨了肠道与大脑神经系统之间细菌关系的新证据及其潜在的致病性和相关性。微生物群、免疫系统、神经系统神经递质合成以及神经可塑性转变之间的相互作用也得到了广泛研究。压力、膳食纤维、益生菌、益生元以及抗生素对肠道-大脑轴的影响正在被研究。多项研究揭示了该轴背后的过程，并促成了基于微生物群的有效预防和治疗药物的开发。因此，这些结果支持了肠道微生物群影响抑郁症这一假说，并为深入了解该疾病的病因及未来治疗方法提供了一个有前景的研究领域。
