Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, 150040, People's Republic of China.
J Nat Med. 2024 Jan;78(1):33-41. doi: 10.1007/s11418-023-01738-2. Epub 2023 Sep 1.
Six new naphthoquinones, euchronin A-F (1-6) and nine known naphthoquinones (7-15), were isolated from the roots of Arnebia euchroma (Royle) Johnst. The structures of the new compounds were confirmed by extensive spectroscopic analyses, including UV, IR, HR-ESI-MS, 1D and 2D NMR. In the present study, we estimated the anti-proliferative activities of these compounds with HaCaT cells. The results indicated that compounds 2 and 4 showed strong anti-proliferative activities at 25 μM, with relative viability at 38.83% and 68.44%, respectively.
从秀丽斑种草（Arnebia euchroma（Royle）Johnst.）的根部分离得到了 6 个新的萘醌类化合物，分别为 euchronin A-F（1-6），以及 9 个已知的萘醌类化合物（7-15）。通过广泛的光谱分析，包括 UV、IR、HR-ESI-MS、1D 和 2D NMR，确定了新化合物的结构。在本研究中，我们用 HaCaT 细胞来评估这些化合物的抗增殖活性。结果表明，化合物 2 和 4 在 25 μM 时表现出很强的抗增殖活性，相对活力分别为 38.83%和 68.44%。
