Department of obstetrics and gynecology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Guangde Road, Yaohai District, 230011, Hefei, China.
BMC Womens Health. 2023 Sep 1;23(1):468. doi: 10.1186/s12905-023-02583-x.
In this study, we analyzed the clinical and epidemiological features of high-risk human papillomavirus (HR-HPV) infection in patients with cervical intraepithelial lesions.
Retrospective analysis was performed on the clinical data of 240 cases of histologically confirmed cervical squamous intraepithelial lesions to determine any correlation between HPV infection characteristics, age distribution, and cervical epithelial lesions.
Patients between the ages of 31 and 40 with cervical intraepithelial lesions were more likely to have high-grade squamous intraepithelial lesions (HSIL; 40.7%) than low-grade squamous intraepithelial lesions (LSIL; 31.3%) (P < 0.05). In patients with HSIL, HR-HPV16, HR-HPV33, and HR-HPV52 were the most common types of HPV infection, while in patients with LSIL, HR-HPV16, HR-HPV52, and HR-HPV58 were the most common types of HPV infection. The highest percentage of single infections occurred in the HSIL group (69.6%), followed by the LSIL group (68.8%). HSIL was present in a significant number of patients (28.6%) aged 30 years and above who tested positive for 12 HPV types but negative for TCT.
The prevalence of HSIL is greatest in younger patients. Patients with cervical epithelial lesions typically have a single infection of a high-risk HPV genotype-HR-HPV16, HR-HPV33, HR-HPV52, or HR-HPV58. Patients aged 30 years and above who test positive for one of 12 types of HPV but negative for TCT are at increased risk for developing HSIL. In order to detect cervical lesions early and begin treatment without delay, colposcopy should be performed regardless of whether or not a high-risk HPV infection is present.
本研究分析了宫颈上皮内病变患者高危型人乳头瘤病毒（HR-HPV）感染的临床和流行病学特征。
对 240 例经组织学证实的宫颈鳞状上皮内病变患者的临床资料进行回顾性分析，以确定 HPV 感染特征、年龄分布与宫颈上皮病变之间的相关性。
31-40 岁年龄组的宫颈上皮内病变患者发生高级别鳞状上皮内病变（HSIL；40.7%）的可能性高于低级别鳞状上皮内病变（LSIL；31.3%）（P<0.05）。在 HSIL 患者中，HR-HPV16、HR-HPV33 和 HR-HPV52 是最常见的 HPV 感染类型，而在 LSIL 患者中，HR-HPV16、HR-HPV52 和 HR-HPV58 是最常见的 HPV 感染类型。单一感染的比例在 HSIL 组最高（69.6%），其次是 LSIL 组（68.8%）。在 TCT 阴性但 12 种 HPV 型均阳性的 30 岁及以上患者中，HSIL 的发生率较高（28.6%）。
年轻患者中 HSIL 的患病率最高。宫颈上皮病变患者通常感染单一高危型 HPV 基因型-HR-HPV16、HR-HPV33、HR-HPV52 或 HR-HPV58。TCT 阴性但 12 种 HPV 型均阳性的 30 岁及以上患者发生 HSIL 的风险增加。为了早期发现宫颈病变并及时开始治疗，无论是否存在高危型 HPV 感染，均应进行阴道镜检查。
