Przybylski Marcin, Pruski Dominik, Wszołek Katarzyna, de Mezer Mateusz, Żurawski Jakub, Jach Robert, Millert-Kalińska Sonja
Gynecology Specialised Practise, 60-682 Poznań, Poland.
Department of Obstetrics and Gynecology, District Public Hospital in Poznan, 60-479 Poznań, Poland.
Pathogens. 2023 Feb 19;12(2):350. doi: 10.3390/pathogens12020350.
The prevalence and distribution of oncogenic human papillomavirus (HPV) genotypes in women who underwent screening for cervical cancer in the Wielkopolska region, Poland, were assessed, and the correlation of genotypes with the histological results was evaluated. Cervical samples were collected from 2969 women for cervical cancer screening. Participants were screened by liquid-based cytology and HPV genotyping ( = 1654) and referred to colposcopy and punch biopsy ( = 616) if recommended. HPV genotypes 16, 31, 52, 66, 53, and 51 are the most frequent types in the studied population. Genotypes 16 and 31 account for nearly one-fifth of the infections of diagnosed HPV infections. HPV 16, 31, and 52 are found in nearly 80% of premalignant HSIL lesions (CIN 2 and CIN 3). That leads to the conclusion that vaccination programs should cover as many types of HPV as possible and shows the urgent need to vaccinate the Polish population with a 9-valent vaccine.
对波兰大波兰地区接受宫颈癌筛查的女性中致癌性人乳头瘤病毒（HPV）基因型的流行情况和分布进行了评估，并评估了基因型与组织学结果的相关性。收集了2969名女性的宫颈样本进行宫颈癌筛查。参与者通过液基细胞学和HPV基因分型进行筛查（n = 1654），如果建议则转诊至阴道镜检查和活检（n = 616）。HPV基因型16、31、52、66、53和51是研究人群中最常见的类型。基因型16和31占确诊HPV感染的近五分之一。在近80%的癌前HSIL病变（CIN 2和CIN 3）中发现了HPV 16、31和52。这得出结论，疫苗接种计划应涵盖尽可能多的HPV类型，并表明迫切需要为波兰人群接种9价疫苗。
