Wang Chunru, Xiang Yingjie, Ma Wenjie, Guo Chuanlong, Wu Xiaochen
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China.
Macromol Biosci. 2024 Feb;24(2):e2300277. doi: 10.1002/mabi.202300277. Epub 2023 Sep 10.
Ulcerative colitis is a chronic inflammatory bowel disease with a high recurrence rate. Natural phytochemical compounds are increasingly being considered as preventative and supportive treatments for this condition. However, the poor water solubility and stability of many of these compounds limit their effectiveness in vivo. To address this issue, fisetin (FT), a natural phytochemical with poor solubility, is stabilized using silk sericin (SS) to create a composite (SS/FT). The therapeutic potential of the SS/FT on ulcerative colitis is extensively investigated, and the results showed that it effectively alleviated the body weight loss and colon length shortening induced by dextran sulfate sodium. Notably, SS/FT downregulated the immune response, decreased colonic histopathological lesions, and reduced the cGAS/STING signal activation. This suggests that SS/FT may offer a promising therapy for treating ulcerative colitis.
溃疡性结肠炎是一种复发率很高的慢性炎症性肠病。天然植物化学化合物越来越被视为这种疾病的预防性和支持性治疗方法。然而，这些化合物中许多的水溶性和稳定性较差，限制了它们在体内的有效性。为了解决这个问题，使用丝胶蛋白（SS）来稳定溶解度较差的天然植物化学物质非瑟酮（FT），以制备一种复合物（SS/FT）。对SS/FT治疗溃疡性结肠炎的潜力进行了广泛研究，结果表明它有效地减轻了葡聚糖硫酸钠诱导的体重减轻和结肠长度缩短。值得注意的是，SS/FT下调了免疫反应，减少了结肠组织病理学损伤，并降低了cGAS/STING信号激活。这表明SS/FT可能为治疗溃疡性结肠炎提供一种有前景的疗法。
