Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp, Nationalestraat 155, 2000 Antwerp, Belgium.
J Med Entomol. 2023 Nov 14;60(6):1262-1268. doi: 10.1093/jme/tjad105.
Transgenesis has emerged as a powerful tool to control arthropod vectors and the diseases they transmit. Here, we highlight the latest developments on transgenic approaches in ticks, Anopheles and Aedes mosquitoes, based on recent findings and significant papers from 2022. We survey topics ranging from population replacement, population suppression, gene drive, sex ratio distortion, public engagement and capacity building, and gene editing in ticks. While presenting these advancements, we discuss the current challenges surrounding the application of arthropod transgenesis for the development of novel vector control strategies.
转基因技术已成为控制节肢动物媒介及其传播疾病的有力工具。本文基于 2022 年的最新发现和重要文献，重点介绍了蜱虫、疟蚊和伊蚊中转基因方法的最新进展。我们调查了与种群替代、种群抑制、基因驱动、性别比例扭曲、公众参与和能力建设以及蜱虫基因编辑等相关的课题。在介绍这些进展的同时，我们还讨论了当前在利用节肢动物转基因技术开发新型媒介控制策略方面所面临的挑战。
