Parasitology and Public Health Unit, Department of Biology, Federal University of Technology, Akure, Nigeria.
Parasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria.
Parasitol Res. 2023 Nov;122(11):2503-2511. doi: 10.1007/s00436-023-07949-6. Epub 2023 Sep 2.
Changes in circulating platelets during different grades of malaria are of major concerns, and its etiology is poorly understood. We appraised and evaluated the role of circulating platelets in the determination of the severity of malaria among a cohort of outpatients living in Ilorin, Nigeria. A hospital-based case-control study of outpatients visiting public health facilities within the locality voluntarily enrolled for this study. Blood samples from 1162 malaise patients were screened using routine microscopy for Plasmodium parasite species identification, and their respective circulating platelet levels were determined. Seven hundred and seventy-five individuals (775, 66.7%, p<0.001) were malaria-positive. Samples from 387 (33.3%) uninfected healthy individuals were used as controls. Individuals with uncomplicated malaria (UCM) and complicated malaria (CM) across age group were notable (p<0.05). Children ≤5 years had the highest number of individuals with CM (103, 45.2%) with a relative risk ratio of 4.005 (95% CI: 2.964-5.413). UCM (471, 40.5%) occurred more than CM (304, 26.2%) (p>0.05) across the groups. The geometric mean, 95% CI, median, and IQR of populations with malaria thrombocytopenia were higher (181, 110.94±2.207, 106.59-115.30, 118.00, and 39.00) than thrombocytosis (78, 624.64±13.131, 598.49-650.79, 623.00, and 208). Seemingly, health controls recorded insignificant morbidity with respect to platelet counts. High P. falciparum parasitemia is inversely correlated with platelet count, and its' morbidity is associated with the manifestation of several malaria pathogenesis. Thrombocytopenia is a silent pathophysiological attribute that can trigger other cofactors during severe malaria disease. Although further studies are pertinent in order to specifically clarify its relevance to clinical disease spectrum.
疟疾不同严重程度下循环血小板的变化是一个主要关注点，但其病因尚不清楚。我们评估和评价了循环血小板在确定尼日利亚伊洛林门诊患者疟疾严重程度中的作用。本研究为一项以医院为基础的门诊病例对照研究，自愿招募当地公共卫生机构就诊的门诊患者。对 1162 名不适患者的血液样本进行了常规显微镜检查，以筛查疟原虫种类鉴定，并测定了各自的循环血小板水平。775 人（775，66.7%，p<0.001）为疟疾阳性。387 名（33.3%）未感染健康个体的样本作为对照。各年龄组单纯性疟疾（UCM）和复杂性疟疾（CM）患者均有显著差异（p<0.05）。≤5 岁的儿童中 CM 患者最多（103，45.2%），相对风险比为 4.005（95%CI：2.964-5.413）。UCM（471，40.5%）比 CM（304，26.2%）更常见（p>0.05）。疟疾血小板减少症人群的几何均数、95%CI、中位数和 IQR 较高（181，110.94±2.207，106.59-115.30，118.00，39.00），血小板增多症（78，624.64±13.131，598.49-650.79，623.00，208）。健康对照者的血小板计数似乎没有明显的发病率。高疟原虫血症与血小板计数呈负相关，其发病率与几种疟疾发病机制的表现有关。血小板减少症是一种无声的病理生理特征，在严重疟疾疾病中可能会引发其他因素。尽管进一步的研究对于明确其与临床疾病谱的相关性很重要。
